Montelukast protects against testes ischemia/reperfusion injury in rats

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dc.contributor.authorÖztürk, Hülya
dc.contributor.authorÖztürk, Hayrettin
dc.contributor.authorGideroğlu, Kaan
dc.contributor.authorTerzi, Hakan
dc.contributor.authorBuğdaycı, Güler
dc.date.accessioned2020-04-30T23:19:19Z
dc.date.available2020-04-30T23:19:19Z
dc.date.issued2010
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionH, Ozturk/0000-0001-5608-5742en_US
dc.descriptionWOS: 000278909600005en_US
dc.descriptionPubMed: 20514280en_US
dc.description.abstractIntroduction: In this study, we investigate the effect of montelukast on histologic damage induced by testicular torsion-detorsion in rats. Methods: Twenty-one male Sprague-Dawley rats were separated into 3 groups, each containing 7 rats. A sham operation was performed in group 1 (control). In group 2 (ischemia-reperfusion [I-R]/untreated), 1-hour detorsion of the testis was performed after 6 hours of unilateral testicular torsion. In group 3 (I-R/dextroamphetamine), after performing the same surgical procedures as in group 2, montelukast was given intraperitoneally. In all experimental rats, ipsilateral orchiectomies were performed for histological examination and tissue malondialdehyde (MDA), glutathione and myeloperoxidase assays. Results: Montelukast treatment significantly decreased the I-R-induced elevation in testes tissue MDA and glutathione levels were found to be preserved. The level of myeloperoxidase (MPO) activity was significantly increased in the testes tissue of the I-R/untreated group. However, in I-R/montelukast treatment group significantly decreased testes tissue MPO level. Histopathologically, the in the group 2 rats, edema, congestion, hemorrhage between seminiferous tubules and necrosis of the germinal cells were predominant features in sections. However, most of the specimens in the montelukast treated group 3 showed grades-I and II injury. Additionally, the testicular injury score was lower in group 3 rats compared with group 2. Conclusion: The current findings demonstrate that the montelukast decreased the severity of testicular injury by reversing the oxidative effects of testes I-R.en_US
dc.identifier.doi10.5489/cuaj.09072en_US
dc.identifier.endpage179en_US
dc.identifier.issn1911-6470
dc.identifier.issn1920-1214
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage174en_US
dc.identifier.urihttps://doi.org/10.5489/cuaj.09072
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3721
dc.identifier.volume4en_US
dc.identifier.wosWOS:000278909600005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCanadian Urological Associationen_US
dc.relation.ispartofCuaj-Canadian Urological Association Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleMontelukast protects against testes ischemia/reperfusion injury in ratsen_US
dc.typeArticleen_US

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