Relation of the Fas and FasL gene polymorphisms with susceptibility to and severity of rheumatoid arthritis

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dc.contributor.authorYıldır, Seyfi
dc.contributor.authorSezgin, Melek
dc.contributor.authorBarlas, İbrahim Ömer
dc.contributor.authorTürköz, Gözde
dc.contributor.authorAnkaralı, Handan
dc.contributor.authorŞahin, Günşah
dc.contributor.authorErdal, Mehmet Emin
dc.date.accessioned2020-04-30T23:31:36Z
dc.date.available2020-04-30T23:31:36Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionAnkarali, Handan Camdeviren/0000-0002-3613-0523; barlas, ibrahim omer/0000-0002-2645-4487; Sahin, Gunsah/0000-0002-4215-6957; Erdal, Mehmet Emin/0000-0002-6191-2930en_US
dc.descriptionWOS: 000324824500025en_US
dc.descriptionPubMed: 23749041en_US
dc.description.abstractTo investigate associations of the Fas and FasL genes polymorphisms with rheumatoid arthritis (RA). One hundred patients with RA and age-, sex- and ethnically matched 101 controls were included. Four polymorphisms of Fas (-670 A > G rs1800682, -1377 G > A rs2234767) and FasL (IVS2nt-124 A > G rs5030772, -844 T > C rs763110) genes were typed from genomic DNA. Genotype distributions and allelic frequencies were compared between patients and control subjects. After the history and clinical examination of patients with RA, in terms of pain, fatigue and general health status were evaluated by visual analogue scale. Thereafter, erythrocyte sedimentation rate, C-reactive protein, blood count and rheumatoid factor levels were measured. The Disease Activity Score-28, Health Assessment Questionnaire and modified Sharp score were used to evaluate the disease activity, functional disability and radiological damage, and their relationships with the Fas and FasL gene polymorphisms were investigated. In patients with RA, CT and TT genotypes of FasL-844, polymorphism were twofold and 4.8-fold higher, and AA genotype of FasL IVS2nt-124 polymorphism was 3.4-fold higher than the control group (respectively, p = 0.05, p = 0.002, p = 0.039). T allele of FasL-844 polymorphism was more frequent in patients than controls (respectively, 52.5 vs. 41.4 %, p = 0.027). Any association was not detected between Fas (-670 A > G, -1377 G > A) and FasL (-844 T > C, IVS2nt-124 A > G) gene polymorphisms with the disease activity scores, functional disability and radiological damage. However, the Fas-670 A > G polymorphism was associated with drug therapy (p = 0.049). The distribution of GG genotype was higher compared to GA or AA genotypes in patients using triple disease-modifying antirheumatic drug therapy (71.4, 14.3 and 14.3 %, respectively). These findings suggest that the -844 T > C and IVS2nt-124 A > G polymorphisms in the FasL gene related with apoptosis may increase genetic susceptibility to RA in a Turkish population. In addition, the Fas-670 A > G gene polymorphism may be associated with disease progression. There is a need for further studies to clarify the genetic role of apoptosis in RA.en_US
dc.identifier.doi10.1007/s00296-013-2793-1en_US
dc.identifier.endpage2645en_US
dc.identifier.issn0172-8172
dc.identifier.issn1437-160X
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage2637en_US
dc.identifier.urihttps://doi.org/10.1007/s00296-013-2793-1
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4344
dc.identifier.volume33en_US
dc.identifier.wosWOS:000324824500025en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofRheumatology Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectFasen_US
dc.subjectFas liganden_US
dc.subjectGene polymorphismen_US
dc.subjectRheumatoid arthritisen_US
dc.titleRelation of the Fas and FasL gene polymorphisms with susceptibility to and severity of rheumatoid arthritisen_US
dc.typeArticleen_US

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