Endothelial Nitric Oxide Synthase Gene Polymorphisms (Promoter-786T/C, Exon 894 G/T and Intron G10T) in Unexplained Female Infertility

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dc.contributor.authorKarataş, Ahmet
dc.contributor.authorEröz, Recep
dc.contributor.authorBahadır, Anzel
dc.contributor.authorKeskin, Fatih
dc.contributor.authorÖzlü, Tülay
dc.contributor.authorÖzyalvaçlı, Mehmet Emin
dc.date.accessioned2020-05-01T12:11:52Z
dc.date.available2020-05-01T12:11:52Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000332502000004en_US
dc.descriptionPubMed: 24504178en_US
dc.description.abstractBackground/Aims: Recent investigations in both males and females show that there may also be some genetic risk factors associated with infertility, and endothelial nitric oxide synthase (eNOS) has important functions in implantation. We aimed to investigate the association of three different polymorphisms of eNOS (promoter -786T/C, exon 894 G/T and intron G10T) with unexplained female infertility. Materials and Methods: Two groups of patients were included in the study: (1) women with unexplained infertility and (2) healthy, fertile women with normal menstrual cycles. eNOS polymorphisms were studied in genomic DNA of each patient by polynnerase chain reaction-restriction fragment length polymorphism method. Results: Forty-one women with unexplained infertility and 40 fertile women were included. Baseline physical characteristics and hormonal parameters of the two groups were similar. For eNOS exon 894 G/T polymorphism, the GG honnozygotes were significantly lower and the heterozygotes GT were significantly higher in the infertile group than in the control group (p < 0.05). eNOS gene polymorphism both for promoter and intron were similar in the two groups (p > 0.05). Conclusion: Altered eNOS protein caused by eNOS exon 894 G/T polymorphism might cause implantation failure, which may be a possible cause of unexplained female infertility. (C) 2014 S. Karger AG, Baselen_US
dc.identifier.doi10.1159/000357442en_US
dc.identifier.endpage93en_US
dc.identifier.issn0378-7346
dc.identifier.issn1423-002X
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage89en_US
dc.identifier.urihttps://doi.org/10.1159/000357442
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6229
dc.identifier.volume77en_US
dc.identifier.wosWOS:000332502000004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKargeren_US
dc.relation.ispartofGynecologic And Obstetric Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjecteNOS polymorphismsen_US
dc.subjectUnexplained female infertilityen_US
dc.subjectNitric oxideen_US
dc.titleEndothelial Nitric Oxide Synthase Gene Polymorphisms (Promoter-786T/C, Exon 894 G/T and Intron G10T) in Unexplained Female Infertilityen_US
dc.typeArticleen_US

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