Endothelial Nitric Oxide Synthase Gene Polymorphisms (Promoter-786T/C, Exon 894 G/T and Intron G10T) in Unexplained Female Infertility
Yükleniyor...
Dosyalar
Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Karger
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background/Aims: Recent investigations in both males and females show that there may also be some genetic risk factors associated with infertility, and endothelial nitric oxide synthase (eNOS) has important functions in implantation. We aimed to investigate the association of three different polymorphisms of eNOS (promoter -786T/C, exon 894 G/T and intron G10T) with unexplained female infertility. Materials and Methods: Two groups of patients were included in the study: (1) women with unexplained infertility and (2) healthy, fertile women with normal menstrual cycles. eNOS polymorphisms were studied in genomic DNA of each patient by polynnerase chain reaction-restriction fragment length polymorphism method. Results: Forty-one women with unexplained infertility and 40 fertile women were included. Baseline physical characteristics and hormonal parameters of the two groups were similar. For eNOS exon 894 G/T polymorphism, the GG honnozygotes were significantly lower and the heterozygotes GT were significantly higher in the infertile group than in the control group (p < 0.05). eNOS gene polymorphism both for promoter and intron were similar in the two groups (p > 0.05). Conclusion: Altered eNOS protein caused by eNOS exon 894 G/T polymorphism might cause implantation failure, which may be a possible cause of unexplained female infertility. (C) 2014 S. Karger AG, Basel
Açıklama
WOS: 000332502000004
PubMed: 24504178
PubMed: 24504178
Anahtar Kelimeler
eNOS polymorphisms, Unexplained female infertility, Nitric oxide
Kaynak
Gynecologic And Obstetric Investigation
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
77
Sayı
2
