Irisin in idiopathic foetal growth restriction

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dc.contributor.authorÇağlar, Mete
dc.contributor.authorGöksu, Mehmet
dc.contributor.authorİsenlik, Bekir Sıtkı
dc.contributor.authorYavuzcan, Ali
dc.contributor.authorYılmaz, Musa
dc.contributor.authorÜstün, Yusuf
dc.contributor.authorKumru, Selahattin
dc.date.accessioned2020-04-30T23:18:44Z
dc.date.available2020-04-30T23:18:44Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionKUMRU, Selahattin/0000-0001-6615-7666en_US
dc.descriptionWOS: 000338541200003en_US
dc.descriptionPubMed: 24789538en_US
dc.description.abstractPurpose The aim of the present study was to compare maternal serum and cord blood irisin levels in females whose pregnancies were or were not complicated by idiopathic foetal growth restriction. Methods A total of 30 subjects participated. The study group consisted of 15 female patients who were referred to our perinatology clinic for delivery because of foetal growth restriction developing in the third trimester. Fifteen females with uncomplicated singleton pregnancies constituted the control group. Irisin levels were assessed in maternal serum, as well as in serum from the umbilical vein and artery. Results The demographic features of the two groups were similar (p > 0.05). Gestational age at delivery and birth weight were higher in females with uncomplicated pregnancies (p = 0.001). Umbilical artery irisin levels were significantly lower in pregnancies complicated by foetal growth restriction compared to controls (p = 0.003). Umbilical artery irisin levels were positively correlated with foetal weight (p = 0.01) and foetal abdominal circumference (measured by ultrasonography) (p = 0.01). Maternal and umbilical vein irisin levels did not differ between the two groups (p > 0.05). Conclusions The data suggest that umbilical artery irisin levels were lower in pregnancies complicated by foetal growth restriction. Such lower irisin levels may contribute to the pathogenesis of this common condition, and metabolic syndrome may be a long-term consequence of idiopathic FGR.en_US
dc.identifier.doi10.1007/s40618-014-0078-5en_US
dc.identifier.endpage624en_US
dc.identifier.issn0391-4097
dc.identifier.issn1720-8386
dc.identifier.issue7en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage619en_US
dc.identifier.urihttps://doi.org/10.1007/s40618-014-0078-5
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3499
dc.identifier.volume37en_US
dc.identifier.wosWOS:000338541200003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal Of Endocrinological Investigationen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFoetal growth restrictionen_US
dc.subjectFat massen_US
dc.subjectIrisinen_US
dc.subjectLean massen_US
dc.subjectMetabolic syndromeen_US
dc.subjectUmbilical arteryen_US
dc.titleIrisin in idiopathic foetal growth restrictionen_US
dc.typeArticleen_US

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