Therapeutic Plasma Exchange in Patients with Neurologic Disorders: Review of 63 Cases

Basit Öğe Kaydı
dc.contributor.authorTombak, Anıl
dc.contributor.authorUçar, Mehmet Ali
dc.contributor.authorAkdeniz, Aydan
dc.contributor.authorYılmaz, Arda
dc.contributor.authorKaleağası, Hakan
dc.contributor.authorSungur, Mehmet Ali
dc.contributor.authorTiftik, Eyüp Naci
dc.date.accessioned2020-04-30T23:34:40Z
dc.date.available2020-04-30T23:34:40Z
dc.date.issued2017
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionTOMBAK, ANIL/0000-0002-7195-1845en_US
dc.descriptionWOS: 000398084800017en_US
dc.descriptionPubMed: 28194064en_US
dc.description.abstractTherapeutic plasma exchange (TPE) is a procedure that reduces circulating autoantibodies of the patients. TPE is commonly used in neurological disorders where autoimmunity plays a major role. We report our experience with regard to the indications, adverse events and outcomes of plasma exchange in neurological disorders. Sixty-three patients were included to this retrospective study. Median age was 48 years (range 1-85), there was a predominance of males. Neurological indications included Guillain-Barre syndrome (n = 22), myasthenia gravis (n = 21), chronic inflammatory demyelinating polyneuropathy (n = 7), polymyositis (n = 3), multifocal motor neuropathy (n = 2), acute disseminated encephalomyelitis (n = 2), neuromyelitis optica (n = 2), multiple sclerosis (n = 2), limbic encephalitis (n = 1) and transverse myelitis (n = 1). TPE was frontline therapy in 57 % of the patients (n = 36). Total number of TPE sessions was 517; median number of sessions per patient was 8 (range 1-66). TPE was done through a central venous access in 97 % and through a peripheral venous access in 3 % of the patients. Human albumin was used as replacement fluid in 49 %, hydroxyethyl starch (HES) in 49 % and fresh frozen plasma in 2 % of the cases. Adverse reactions were recorded in 60 % of the patients. Total ratio of complications in 517 TPE procedures was 10.8 % and these were mild and manageable such as allergic reactions and hypotension. Overall response rate was 81 %. Interestingly, complication and response rates were similar in both HES and human albumin groups. We conclude that TPE is an effective treatment in neurologic diseases in which autoimmunity plays an important role in the pathogenesis and HES can be used instead of albumin as replacement fluid in these disorders, since it is cost-effective, has similar efficacy and complication rates.en_US
dc.identifier.doi10.1007/s12288-016-0661-3en_US
dc.identifier.endpage105en_US
dc.identifier.issn0971-4502
dc.identifier.issn0974-0449
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage97en_US
dc.identifier.urihttps://doi.org/10.1007/s12288-016-0661-3
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5202
dc.identifier.volume33en_US
dc.identifier.wosWOS:000398084800017en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer Indiaen_US
dc.relation.ispartofIndian Journal Of Hematology And Blood Transfusionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTherapeutic plasma exchangeen_US
dc.subjectGuillain-Barre syndromeen_US
dc.subjectMyasthenia gravisen_US
dc.subjectDemyelinating diseaseen_US
dc.subjectPolyneuropathyen_US
dc.titleTherapeutic Plasma Exchange in Patients with Neurologic Disorders: Review of 63 Casesen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
5202.pdf
Boyut:
430.51 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu