Effects of topical azithromycin, moxifloxacin, and povidone iodine on conjunctival bacterial flora in patients undergoing intravitreal injection

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dc.contributor.authorTeberik, Kuddusi
dc.contributor.authorEski, Mehmet Tahir
dc.contributor.authorÇalışkan, Emel
dc.contributor.authorKılınçel, Özge
dc.contributor.authorKaya, Murat
dc.contributor.authorAnkaralı, Handan
dc.date.accessioned2020-05-01T09:12:05Z
dc.date.available2020-05-01T09:12:05Z
dc.date.issued2019
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000455788400006en_US
dc.descriptionPubMed: 30652764en_US
dc.description.abstractPurpose: To compare effects of 5% topical povidone iodine with prophylactic topical azithromycin and moxifloxacin on bacterial flora in patients undergoing intravitreal injection. Methods: A total of 132 patients were randomly assigned to receive treatment with azithromycin or moxifloxacin, or no treatment (control group). In total, 528 specimens were obtained at the time of admission, 4 days before intravitreal injection, 4 days after intravitreal injection, and 8 days after intravitreal injection. Samples were immediately sent to the microbiology laboratory for incubation. Results: The microorganism observed most frequently was coagulase-negative Staphylococcus (23.8%). When the results of samples obtained on Day 4 before injection were assessed, growth of coagulase-negative Staphylococcus was significantly lower in the moxifloxacin group, compared with controls (p=0.049). Acinetobacter baumannii continued to grow after administration of azithromycin (p=0.033). When the results of four days after intravitreal injection were evaluated, growth of coagulase-negative Staphylococcus was higher in controls, compared with patients who received azithromycin or moxifloxacin (p=0.004). Eradication rate was significantly higher in the moxifloxacin group than in the control group (p=0.001). Samples obtained on Day 8 after intravitreal injection showed similar levels of bacterial growth in all groups (p=0.217). Conclusion: Moxifloxacin was more effective than 5% povidone iodine in controlling the growth of conjunctival bacterial flora. Use of moxifloxacin in combination with 5% povidone iodine resulted in a synergistic effect.en_US
dc.identifier.doi10.5935/0004-2749.20190008en_US
dc.identifier.endpage31en_US
dc.identifier.issn0004-2749
dc.identifier.issn1678-2925
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage25en_US
dc.identifier.urihttps://doi.org/10.5935/0004-2749.20190008
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5873
dc.identifier.volume82en_US
dc.identifier.wosWOS:000455788400006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherConsel Brasil Oftalmologiaen_US
dc.relation.ispartofArquivos Brasileiros De Oftalmologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAzithromycinen_US
dc.subjectConjunctiva/microbiologyen_US
dc.subjectIntravitreal injectionen_US
dc.subjectMoxifloxacinen_US
dc.subjectPovidone-iodineen_US
dc.titleEffects of topical azithromycin, moxifloxacin, and povidone iodine on conjunctival bacterial flora in patients undergoing intravitreal injectionen_US
dc.typeArticleen_US

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