Honey: An Advanced Antimicrobial and Wound Healing Biomaterial for Tissue Engineering Applications

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dc.authoriddiver, carl/0000-0002-8743-1182
dc.authoridYupanqui Mieles, Joel/0000-0002-2256-2480
dc.authoridBartolo, Paulo/0000-0003-3683-726X
dc.authoridAslan, Enes/0000-0002-1849-2715
dc.authoridHumphreys, Gavin/0000-0002-9138-0859
dc.authorwosidBartolo, Paulo/F-2421-2013
dc.contributor.authorYupanqui Mieles, Joel
dc.contributor.authorVyas, Cian
dc.contributor.authorAslan, Enes
dc.contributor.authorHumphreys, Gavin
dc.contributor.authorDiver, Carl
dc.contributor.authorBartolo, Paulo
dc.date.accessioned2023-07-26T11:51:12Z
dc.date.available2023-07-26T11:51:12Z
dc.date.issued2022
dc.departmentDÜ, Gümüşova Meslek Yüksekokulu, Makine ve Metal Teknolojileri Bölümüen_US
dc.description.abstractHoney was used in traditional medicine to treat wounds until the advent of modern medicine. The rising global antibiotic resistance has forced the development of novel therapies as alternatives to combat infections. Consequently, honey is experiencing a resurgence in evaluation for antimicrobial and wound healing applications. A range of both Gram-positive and Gram-negative bacteria, including antibiotic-resistant strains and biofilms, are inhibited by honey. Furthermore, susceptibility to antibiotics can be restored when used synergistically with honey. Honey's antimicrobial activity also includes antifungal and antiviral properties, and in most varieties of honey, its activity is attributed to the enzymatic generation of hydrogen peroxide, a reactive oxygen species. Non-peroxide factors include low water activity, acidity, phenolic content, defensin-1, and methylglyoxal (Leptospermum honeys). Honey has also been widely explored as a tissue-regenerative agent. It can contribute to all stages of wound healing, and thus has been used in direct application and in dressings. The difficulty of the sustained delivery of honey's active ingredients to the wound site has driven the development of tissue engineering approaches (e.g., electrospinning and hydrogels). This review presents the most in-depth and up-to-date comprehensive overview of honey's antimicrobial and wound healing properties, commercial and medical uses, and its growing experimental use in tissue-engineered scaffolds.en_US
dc.description.sponsorshipTurkish Ministry of National Education, an Engineering and Physical Sciences Research Council (UK) Doctoral Prize Fellowship [EP/R513131/1]; Matoke Holdingsen_US
dc.description.sponsorshipThis research was funded by the Turkish Ministry of National Education, an Engineering and Physical Sciences Research Council (UK) Doctoral Prize Fellowship (EP/R513131/1), and Matoke Holdings.en_US
dc.identifier.doi10.3390/pharmaceutics14081663
dc.identifier.issn1999-4923
dc.identifier.issue8en_US
dc.identifier.pmid36015289en_US
dc.identifier.scopus2-s2.0-85137391584en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3390/pharmaceutics14081663
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12514
dc.identifier.volume14en_US
dc.identifier.wosWOS:000845748100001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorAslan, Enes
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofPharmaceuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectHoney; Antimicrobial; Hydrogen Peroxide; Antibiotic Resistance; Wound Healing; Tissue Engineeringen_US
dc.subjectMedical Grade Honey; Antibacterial Activity; In-Vitro; Manuka Honey; Hydrogen-Peroxide; Staphylococcus-Aureus; Reactive Oxygen; Glucose-Oxidase; Escherichia-Coli; Water Activityen_US
dc.titleHoney: An Advanced Antimicrobial and Wound Healing Biomaterial for Tissue Engineering Applicationsen_US
dc.typeReview Articleen_US

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