Honey: An Advanced Antimicrobial and Wound Healing Biomaterial for Tissue Engineering Applications
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Date
2022
Journal Title
Journal ISSN
Volume Title
Publisher
Mdpi
Access Rights
info:eu-repo/semantics/openAccess
Abstract
Honey was used in traditional medicine to treat wounds until the advent of modern medicine. The rising global antibiotic resistance has forced the development of novel therapies as alternatives to combat infections. Consequently, honey is experiencing a resurgence in evaluation for antimicrobial and wound healing applications. A range of both Gram-positive and Gram-negative bacteria, including antibiotic-resistant strains and biofilms, are inhibited by honey. Furthermore, susceptibility to antibiotics can be restored when used synergistically with honey. Honey's antimicrobial activity also includes antifungal and antiviral properties, and in most varieties of honey, its activity is attributed to the enzymatic generation of hydrogen peroxide, a reactive oxygen species. Non-peroxide factors include low water activity, acidity, phenolic content, defensin-1, and methylglyoxal (Leptospermum honeys). Honey has also been widely explored as a tissue-regenerative agent. It can contribute to all stages of wound healing, and thus has been used in direct application and in dressings. The difficulty of the sustained delivery of honey's active ingredients to the wound site has driven the development of tissue engineering approaches (e.g., electrospinning and hydrogels). This review presents the most in-depth and up-to-date comprehensive overview of honey's antimicrobial and wound healing properties, commercial and medical uses, and its growing experimental use in tissue-engineered scaffolds.
Description
Keywords
Honey; Antimicrobial; Hydrogen Peroxide; Antibiotic Resistance; Wound Healing; Tissue Engineering, Medical Grade Honey; Antibacterial Activity; In-Vitro; Manuka Honey; Hydrogen-Peroxide; Staphylococcus-Aureus; Reactive Oxygen; Glucose-Oxidase; Escherichia-Coli; Water Activity
Journal or Series
Pharmaceutics
WoS Q Value
Q1
Scopus Q Value
Q1
Volume
14
Issue
8
