Correlation of ischemia-modified albumin levels and histopathologic findings in experimental ovarian torsion

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dc.contributor.authorYıldırım, Ahmet
dc.contributor.authorYıldırım, Şule
dc.contributor.authorTopaloğlu, Naci
dc.contributor.authorTekin, Mustafa
dc.contributor.authorKüçük, Adem
dc.contributor.authorErdem, Havva
dc.contributor.authorÇakır, Dilek Ülker
dc.date.accessioned2020-04-30T22:41:50Z
dc.date.available2020-04-30T22:41:50Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionYildirim, Sule/0000-0002-1815-808Xen_US
dc.descriptionWOS: 000393518500002en_US
dc.descriptionPubMed: 27239631en_US
dc.description.abstractObjectives: Ischemia modified albumin (IMA) levels significantly increased and may be used as a diagnostic marker in ovarian torsion. The aim of this study is to investigate whether there was any correlation between IMA levels and histopathologic changes in experimental ovarian torsion. Material and methods: Fourteen Sprague-Dawley rats, each weighing 220-250 g were divided randomly into 2 groups; in Group 1, the control group (n = 7), only laparotomy was performed and in Group 2, the experimental group (n = 7), ovarian torsion was performed. Ischemia was performed for 3 h; following the ischemia period, the torsion was relieved by detwisting the adnexa and then the ovarian I/R protocol was applied for 3 h. Blood samples were taken from all of the rats to measure the IMA levels and the ovaries were surgically removed for histologic examination. A blinded pathologist examined and scored the samples. Results: The median (minimum-maximum) IMA values were 921.00 (870.00-966.00) ABSUs in the ovarian torsion group and 853.00 (782.00-869.00) ABSUs in the control group. The difference was statistically significant. In the correlation analysis, a significant and strong correlationwas found between IMA levels and histopathologic changes (Spearman's rho = vertical bar 0.987, p < 0.001). Conclusion: Positive correlation was found between the IMA levels and the histopathologic severity of the disease. This finding is important for both diagnosis of the disease and patient follow-up. As a new marker in ovarian torsion, IMA may also indicate the severity of the ovarian histopathology. Copyright (C) 2016 The Emergency Medicine Association of Turkey. Production and hosting by Elsevier B.V. on behalf of the Owner.en_US
dc.identifier.doi10.1016/j.tjem.2016.02.004en_US
dc.identifier.endpage11en_US
dc.identifier.issn1304-7361
dc.identifier.issue1en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage8en_US
dc.identifier.urihttps://doi.org/10.1016/j.tjem.2016.02.004
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3255
dc.identifier.volume16en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofTurkish Journal Of Emergency Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIschemia-modified albuminen_US
dc.subjectOvaryen_US
dc.subjectPathologyen_US
dc.subjectRatsen_US
dc.titleCorrelation of ischemia-modified albumin levels and histopathologic findings in experimental ovarian torsionen_US
dc.typeArticleen_US

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