Maternal exposure to a continuous 900-MHz electromagnetic field provokes neuronal loss and pathological changes in cerebellum of 32-day-old female rat offspring

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dc.contributor.authorOdacı, Ersan
dc.contributor.authorHancı, Hatice
dc.contributor.authorİkinci, Ayşe
dc.contributor.authorSönmez, Osman Fikret
dc.contributor.authorAslan, Ali
dc.contributor.authorŞahin, Arzu
dc.contributor.authorBaş, Orhan
dc.date.accessioned2020-04-30T23:19:05Z
dc.date.available2020-04-30T23:19:05Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000381842500010en_US
dc.descriptionPubMed: 26391347en_US
dc.description.abstractLarge numbers of people are unknowingly exposed to electromagnetic fields (EMF) from wireless devices. Evidence exists for altered cerebellar development in association with prenatal exposure to EMF. However, insufficient information is still available regarding the effects of exposure to 900 megahertz (MHz) EMF during the prenatal period on subsequent postnatal cerebellar development. This study was planned to investigate the 32-day-old female rat pup cerebellum following exposure to 900 MHz EMF during the prenatal period using stereological and histopathological evaluation methods. Pregnant rats were divided into control, sham and EMF groups. Pregnant EMF group (PEMFG) rats were exposed to 900 MHz EMF for 1 h inside an EMF cage during days 13-21 of pregnancy. Pregnant sham group (PSG) rats were also placed inside the EMF cage during days 13-21 of pregnancy for 1 h, but were not exposed to any EMF. No procedure was performed on the pregnant control group (PCG) rats. Newborn control group (CG) rats were obtained from the PCG mothers, newborn sham group (SG) rats from the PSG and newborn EMF group (EMFG) rats from the PEMFG rats. The cerebellums of the newborn female rats were extracted on postnatal day 32. The number of Purkinje cells was estimated stereologically, and histopathological evaluations were also performed on cerebellar sections. Total Purkinje cell numbers calculated using stereological analysis were significantly lower in EMFG compared to CG (p < 0.05) and SG (p < 0.05). Additionally, some pathological changes such as pyknotic neurons with dark cytoplasm were observed in EMFG sections under light microscopy. In conclusion, our study results show that prenatal exposure to EMF affects the development of Purkinje cells in the female rat cerebellum and that the consequences of this pathological effect persist after the postnatal period. (C) 2015 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.jchemneu.2015.09.002en_US
dc.identifier.endpage110en_US
dc.identifier.issn0891-0618
dc.identifier.issn1873-6300
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage105en_US
dc.identifier.urihttps://doi.org/10.1016/j.jchemneu.2015.09.002
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3643
dc.identifier.volume75en_US
dc.identifier.wosWOS:000381842500010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofJournal Of Chemical Neuroanatomyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectElectromagnetic fielden_US
dc.subjectFemale raten_US
dc.subjectCerebellumen_US
dc.subjectPurkinje cellen_US
dc.subjectStereologyen_US
dc.titleMaternal exposure to a continuous 900-MHz electromagnetic field provokes neuronal loss and pathological changes in cerebellum of 32-day-old female rat offspringen_US
dc.typeArticleen_US

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