Melatonin reduces oxidative stress in the rat lens due to radiation-induced oxidative injury

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dc.contributor.authorTaysı, Seyithan
dc.contributor.authorMemişoğulları, Ramazan
dc.contributor.authorKoç, Mehmet
dc.contributor.authorYazıcı, Ahmet Taylan
dc.contributor.authorAslankurt, Murat
dc.contributor.authorGümüştekin, Kenan
dc.contributor.authorÖzder, Hasan Tahsin
dc.date.accessioned2020-04-30T23:19:11Z
dc.date.available2020-04-30T23:19:11Z
dc.date.issued2008
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionTAYSI, Seyithan/0000-0003-1251-3148; KOC, MEHMET/0000-0003-1504-2900; yilmaz, adnan/0000-0001-9769-9791en_US
dc.descriptionWOS: 000260573400003en_US
dc.descriptionPubMed: 18979314en_US
dc.description.abstractPurpose: The aim of this study was to evaluate the antioxidant role of melatonin against radiation-induced cataract in the rat lens after total cranial irradiation with a single 5 Gray (Gy) dose of gamma irradiation. Materials and methods: Twenty-eight Sprague-Dawley rats were used for the experiment.The rats were randomly divided into four equal groups. The control group did not receive melatonin or irradiation but received both 0.1ml physiological saline intraperitoneally and sham irradiation. The irradiation (IR) group received 5 Gy gamma irradiation to the total cranium as a single dose plus 0.1ml physiological saline intraperitoneally. The melatonin plus IR group received irradiation to the total cranium plus 5mg/kg/day melatonin intraperitoneally. The melatonin group received only 5mg/kg/day melatonin plus sham-irradiation. Biochemical parameters measured in murine lenses were carried out using spectrophotometric techniques. Results: Lens antioxidant capacity, as measured by levels of total superoxide scavenger activity (TSSA), non-enzymatic superoxide scavenger activity (NSSA) and glutathione reductase (GRD) activity, significantly increased in melatonin, control and melatonin plus IR groups when compared with the IR group. Lens glutathione-S-transferase (GST) activity significantly increased in control and melatonin groups when compared with the IR group. Lens malondialdehyde (MDA) levels significantly increased in the IR group when compared with control, melatonin and melatonin plus IR groups. Lens TSSA and NSSA activities significantly decreased in control and melatonin plus IR groups when compared with the melatonin group. Lens GST activity significantly increased in the control group when compared with melatonin plus IR group. Lens GRD activity significantly increased in melatonin and melatonin plus IR groups when compared with control group. Conclusions: Melatonin reduces oxidative stress markers and augments anti-oxidant capacity in the rat lens.en_US
dc.identifier.doi10.1080/09553000802390932en_US
dc.identifier.endpage808en_US
dc.identifier.issn0955-3002
dc.identifier.issn1362-3095
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage803en_US
dc.identifier.urihttps://doi.org/10.1080/09553000802390932
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3678
dc.identifier.volume84en_US
dc.identifier.wosWOS:000260573400003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofInternational Journal Of Radiation Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMelatoninen_US
dc.subjectantioxidantsen_US
dc.subjectradioprotectorsen_US
dc.subjectantioxidant enzymesen_US
dc.subjectirradiationen_US
dc.subjectfree radicalsen_US
dc.subjectoxidative stressen_US
dc.titleMelatonin reduces oxidative stress in the rat lens due to radiation-induced oxidative injuryen_US
dc.typeArticleen_US

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