Asymmetric dimethylarginine is not a good predictor of ischemia using myocardial perfusion scintigraphy

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dc.contributor.authorErkan, Melih Engin
dc.contributor.authorAşık, Muhammet
dc.contributor.authorUçgun, Taner
dc.contributor.authorYıldız, Nilgün
dc.contributor.authorYılmaz, Ayşe
dc.contributor.authorAslantaş, Yusuf
dc.contributor.authorDoğan, Ahmet Semih
dc.date.accessioned2020-04-30T22:39:57Z
dc.date.available2020-04-30T22:39:57Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000359064200034en_US
dc.descriptionPubMed: 26422873en_US
dc.description.abstractBackground/aim: Asymmetric dimethylarginine (ADMA) plays role in the pathogenesis of coronary artery disease and related mortality and morbidity through a number of mechanisms. We hypothesized that plasma ADMA levels would be increased in the presence of reversible ischemia as measured by GATED single photon emission computed tomography (SPECT) myocardial perfusion scintigraphy (MPS). Materials and methods: Fasting i.v. blood samples were drawn before testing. All patients underwent 99mTc-sestamibi GATED SPECT MPS with a one-day stress-rest protocol; the images were visually analyzed. Post-stress GATED parameters, including ejection fraction, end systolic and end diastolic volumes, and automatic stress defect scores, were recorded. Results: The plasma ADMA levels were higher in the ischemic group than in the non-ischemic group (0.46 +/- 0.19 vs. 0.40 +/- 0.15; P = 0.016). Plasma ADMA levels (odds ratio [OR] = 13.5; 95% confidence interval [CI] = 1.7-109.01; P = 0.015) and sex (OR = 2.49, 95% CI = 1.18-5.26; P = 0.017) were independent predictors of ischemia. There was no linear correlation between plasma ADMA levels and both the GATED SPECT and stress test parameters. Conclusion: Our data support the hypothesis that increased baseline ADMA levels are independently related with the presence of reversible ischemia.en_US
dc.identifier.doi10.3906/sag-1404-32en_US
dc.identifier.endpage958en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage954en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1404-32
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2868
dc.identifier.volume45en_US
dc.identifier.wosWOS:000359064200034en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAsymmetric dimethylarginineen_US
dc.subjectsingle photon emission computed tomographyen_US
dc.subjectischemiaen_US
dc.titleAsymmetric dimethylarginine is not a good predictor of ischemia using myocardial perfusion scintigraphyen_US
dc.typeArticleen_US

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