Evaluation of the Relationship Between Disease Severity and Viral Cycle Threshold Value in COVID-19 Patients

Basit Öğe Kaydı
dc.authorscopusid57214675559
dc.authorscopusid35571535100
dc.authorscopusid57196044228
dc.authorscopusid58028349500
dc.authorscopusid57224640623
dc.authorscopusid58028349600
dc.authorscopusid57205202990
dc.contributor.authorHabiloğlu, Arif Doğan
dc.contributor.authorÖztürk, Cihadiye Elif
dc.contributor.authorÖzel, Mehmet Ali
dc.contributor.authorDemircan, Serkan
dc.contributor.authorUludoğan, Burcu Ceren
dc.contributor.authorMemiş, Nagihan
dc.contributor.authorAtaoğlu, Özlem
dc.date.accessioned2023-07-26T11:50:31Z
dc.date.available2023-07-26T11:50:31Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalıen_US
dc.description.abstractObjective: There is a positive and significant relationship between severity and viral load in some viral diseases. Studies on the relationship between SARS-CoV-2 viral load at diagnosis and severity of coronavirus disease-2019 (COVID-19) have yielded conflicting results. Therefore, we aimed to evaluate the relationship between viral load and the clinical status of patients with COVID-19. Methods: Data of the patients diagnosed with COVID-19 and admitted to our center between May 01 and June 31, 2020, were retrospectively reviewed. The patients were divided into two groups according to their clinical characteristics as mild-moderate and severe. The demographic, laboratory, clinical, and radiological data were retrieved from electronic folders. Results: The entire cohort included 285 patients; 254 had a mild-moderate clinical course, and 31 had a severe course. Statistical analyses revealed that SARS-CoV-2 viral load was not associated with symptom duration and clinical status (p>0.05). According to multivariate logistic regression analysis, only ferritin, C-reactive protein, and lactate dehydro-genase elevations were positively correlated with severe clinical course. (p<0.05). Conclusion: We do not recommend using viral load to predict disease severity in COVID-19. We also found that only ferritin, C-reactive protein, and lactate dehydrogenase accompanied severe clinical course. © 2022, DOC Design and Informatics Co. Ltd.. All rights reserved.en_US
dc.identifier.doi10.36519/kd.2022.4216
dc.identifier.endpage219en_US
dc.identifier.issn1301-143X
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85144609374en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage215en_US
dc.identifier.urihttps://doi.org/10.36519/kd.2022.4216
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12367
dc.identifier.volume35en_US
dc.identifier.wosWOS:000957727600002en_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorMemiş, Nagihan
dc.language.isotren_US
dc.publisherDOC Design and Informatics Co. Ltd.en_US
dc.relation.ispartofKlimik Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectclinical severityen_US
dc.subjectCOVID-19en_US
dc.subjectcycle thresholden_US
dc.subjectC reactive proteinen_US
dc.subjectferritinen_US
dc.subjectlactate dehydrogenaseen_US
dc.subjectArticleen_US
dc.subjectclinical featureen_US
dc.subjectcohort analysisen_US
dc.subjectcoronavirus disease 2019en_US
dc.subjectcycle threshold valueen_US
dc.subjectdisease severityen_US
dc.subjecthumanen_US
dc.subjectretrospective studyen_US
dc.subjectvirus loaden_US
dc.titleEvaluation of the Relationship Between Disease Severity and Viral Cycle Threshold Value in COVID-19 Patientsen_US
dc.title.alternativeCOVID-19 Hastalarında Hastalık Şiddeti ile Viral Döngü Eşik Değeri Arasındaki İlişkinin Değerlendirilmesien_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
12367.pdf
Boyut:
199.18 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu