Evaluation of the Relationship Between Disease Severity and Viral Cycle Threshold Value in COVID-19 Patients
Yükleniyor...
Dosyalar
Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
DOC Design and Informatics Co. Ltd.
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: There is a positive and significant relationship between severity and viral load in some viral diseases. Studies on the relationship between SARS-CoV-2 viral load at diagnosis and severity of coronavirus disease-2019 (COVID-19) have yielded conflicting results. Therefore, we aimed to evaluate the relationship between viral load and the clinical status of patients with COVID-19. Methods: Data of the patients diagnosed with COVID-19 and admitted to our center between May 01 and June 31, 2020, were retrospectively reviewed. The patients were divided into two groups according to their clinical characteristics as mild-moderate and severe. The demographic, laboratory, clinical, and radiological data were retrieved from electronic folders. Results: The entire cohort included 285 patients; 254 had a mild-moderate clinical course, and 31 had a severe course. Statistical analyses revealed that SARS-CoV-2 viral load was not associated with symptom duration and clinical status (p>0.05). According to multivariate logistic regression analysis, only ferritin, C-reactive protein, and lactate dehydro-genase elevations were positively correlated with severe clinical course. (p<0.05). Conclusion: We do not recommend using viral load to predict disease severity in COVID-19. We also found that only ferritin, C-reactive protein, and lactate dehydrogenase accompanied severe clinical course. © 2022, DOC Design and Informatics Co. Ltd.. All rights reserved.
Açıklama
Anahtar Kelimeler
clinical severity, COVID-19, cycle threshold, C reactive protein, ferritin, lactate dehydrogenase, Article, clinical feature, cohort analysis, coronavirus disease 2019, cycle threshold value, disease severity, human, retrospective study, virus load
Kaynak
Klimik Dergisi
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
35
Sayı
4
