Abnormal sperm morphology in mouse germ cells after short-term exposures to acetamiprid, propineb, and their mixture

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dc.contributor.authorRasgele, Pınar Göç
dc.date.accessioned2020-04-30T22:38:55Z
dc.date.available2020-04-30T22:38:55Z
dc.date.issued2014
dc.departmentDÜ, Ziraat Fakültesi, Biyosistem Mühendisliği Bölümüen_US
dc.descriptionWOS: 000333849700005en_US
dc.descriptionPubMed: 24535295en_US
dc.description.abstractPesticides are one of the most potent environmental contaminants, which accumulate in biotic and abiotic components of ecosystems. Acetamiprid (Acm), a neonicotinoid insecticide, and Propineb (Pro), a dithiocarbamate fungicide, are widely used to control sucking insects and fungal infections on crops, respectively. The present study was undertaken to investigate the genotoxic effects of these compounds, individually and in mixtures, in mouse germ cells by using the sperm morphology assay. Mice were injected intraperitoneally with 0.625, 1.25, and 2.50 mu g mL(-1) of Acm, 12.5, 25, and 50 mu g mL(-1) of Pro, and their mixture at the same concentrations over 24 and 48 h. Acm did not significantly increase the percentage of abnormal sperm at any concentration. The frequency of abnormal sperm significantly increased after 24 and 48 h of exposure to 50 mu g mL(-1) of Pro. The mixtures of 2.50 mu g mL(-1) of Acm and 50 mu g mL(-1) of Pro induced sperm abnormalities antagonistically both after 24 and 48 h of exposure. Results suggest that Acm was non-genotoxic for mouse germ cells, while Pro may have been a germ cell mutagen due to the observed increase in the frequency of sperm abnormalities. However, to gain better insight into the mutagenicity and DNA damaging potential of both of these pesticides, further studies at molecular level should be done.en_US
dc.description.sponsorshipDuzce University Scientific Research Fund, TurkeyDuzce University [2011.05.01.070]en_US
dc.description.sponsorshipThis study was a part of a project entitled "Micronucleus induction in mice bone marrow and human lymphocytes after exposure to mixture of pesticides acetamiprid-propineb" and supported by the Duzce University Scientific Research Fund [Project Number = 2011.05.01.070], Turkey. The author thanks Meral Kekecoglu for support and Zekiye Kiris and Salih Tunc Kaya for laboratory assistance.en_US
dc.identifier.doi10.2478/10004-1254-65-2014-2408en_US
dc.identifier.endpage56en_US
dc.identifier.issn0004-1254
dc.identifier.issn1848-6312
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage47en_US
dc.identifier.urihttps://doi.org/10.2478/10004-1254-65-2014-2408
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2520
dc.identifier.volume65en_US
dc.identifier.wosWOS:000333849700005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherInst Medical Research & Occupational Healthen_US
dc.relation.ispartofArhiv Za Higijenu Rada I Toksikologiju-Archives Of Industrial Hygiene And Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectcombined effectsen_US
dc.subjectpesticide mixtureen_US
dc.subjectsperm morphology assayen_US
dc.titleAbnormal sperm morphology in mouse germ cells after short-term exposures to acetamiprid, propineb, and their mixtureen_US
dc.typeArticleen_US

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