Anti-Mullerian hormone levels during hormonal contraception in women with polycystic ovary syndrome
Yükleniyor...
Dosyalar
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Ireland Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: The use of oral contraceptive (OC) pills alters the characteristic features of polycystic ovary syndrome (PCOS) complicating the diagnosis of this disease. Anti-Mullerian hormone (AMH) levels are high in PCOS patients and are stable throughout the menstrual cycle in healthy subjects. This study examined the influence of hormonal suppression with OC therapy on the serum AMH levels in women with PCOS and with normal menstrual cycles. Study design: Thirty women with PCOS and 15 women with normal menstrual cycles were enrolled in this prospective study. Serum was collected from the subjects during the early follicular phase of the menstrual cycle and after the sixth cycle of oral contraceptive therapy, and stored frozen until assayed. The effect of OC therapy on the serum AMH, estradiol (EA luteinizing hormone (LH), follicle-stimulating hormone (FSH), free testosterone, total testosterone, and dehydroepiandrosterone sulfate (DHEA-S) levels was studied. In addition, ovarian volume and follicle count were assessed. Results: The serum AMH levels in PCOS patients were significantly higher than in healthy women at baseline (+/- S.D.; 5.49 +/- 2.26 and 1.93 +/- 0.51 ng/ml, respectively; p = 0.001). After six cycles of OC therapy, no significant changes in the AMH levels were observed in either the PCOS patients or normally cycling women. Ultrasound showed significant reductions in ovarian volume and follicle number and size at 6 months in both groups. Conclusion: Although significant reductions were observed in ovarian volume and follicle number, 6 months of contraceptive therapy did not change the serum AMH concentration in either group. AMH may be considered a new marker in PCOS patients who are already on contraceptive treatment. (C) 2007 Elsevier Ireland Ltd. All rights reserved.
Açıklama
WOS: 000250695700012
PubMed: 17335955
PubMed: 17335955
Anahtar Kelimeler
anti-mullerian hormone, mullerian-inhibiting substance, Polycystic ovary syndrome, oral contraceptive pills
Kaynak
European Journal Of Obstetrics Gynecology And Reproductive Biology
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
134
Sayı
2
