STAT3 Expression and Correlation Between Ki-67 and PHH3 in Meningiomas: Is it Possible to Predict Recurrence?

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dc.authorscopusid57223086874
dc.authorscopusid57193240432
dc.contributor.authorKantarcıoğlu Coşkun, Sinem
dc.contributor.authorKılıç, Güven
dc.date.accessioned2023-07-26T11:58:30Z
dc.date.available2023-07-26T11:58:30Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalıen_US
dc.description.abstractAim: The aim of this study was to investigate the correlation between PHH3 and ki-67 labeling index, and the association of STAT3 expression with mitotic index, grade by World Health Organization 2016 classification, and clinicopathological features of meningioma cases. Material and Methods: A total of 25 meningioma cases from the archives of the Department of Pathology, Düzce University School of Medicine, diagnosed between 2012 and 2021 were included in the study. The mitotic count from the ten fields with the highest number of mitotic figures was determined. Immunohistochemistry was performed on the formalin-fixed, paraffin-embedded tissue blocks to determine STAT3, ki-67, and PHH3 expression. STAT3 was scored between 0 and 3 points according to staining intensity. Staining percentages for STAT3 were determined using a manual count of stained cells and the total number of tumor cells. The ki-67 labeling index was determined as a percentage by a manual count. For PHH3, the total number of immunostained mitotic figures per 10 high-power fields were evaluated in each case. Results: A statistically significant difference was found in terms of the percentage of STAT3 staining between the tumor grades (p=0.047). STAT3 expression was significantly higher in cases with high tumor grades. A moderate positive correlation was found between ki-67 and PHH3 when calculated as a percentage in the area with the highest mitotic index by manual counting (r=0.621, p=0.001). Conclusion: A combination of ki-67, PHH3, and STAT3 will be useful in the grading of meningiomas and predict the recurrence. © 2022, Duzce University Medical School. All rights reserved.en_US
dc.identifier.doi10.18678/dtfd.1124225
dc.identifier.endpage206en_US
dc.identifier.issn1307-671X
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85136261136en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage201en_US
dc.identifier.trdizinid1115679en_US
dc.identifier.urihttps://doi.org/10.18678/dtfd.1124225
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1115679
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13505
dc.identifier.volume24en_US
dc.identifier.wosWOS:001207163500019en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorKantarcıoğlu Coşkun, Sinem
dc.language.isoenen_US
dc.publisherDuzce University Medical Schoolen_US
dc.relation.ispartofDüzce Tıp Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectki-67en_US
dc.subjectMeningiomaen_US
dc.subjectPHH3en_US
dc.subjectSTAT3en_US
dc.subjecttumor gradeen_US
dc.subjecthistone H3en_US
dc.subjectKi 67 antigenen_US
dc.subjectphosphorylated histone h3en_US
dc.subjectSTAT3 proteinen_US
dc.subjectunclassified drugen_US
dc.subjectadulten_US
dc.subjectageden_US
dc.subjectArticleen_US
dc.subjectbone metastasisen_US
dc.subjectcancer gradingen_US
dc.subjectcancer prognosisen_US
dc.subjectcancer recurrenceen_US
dc.subjectcell counten_US
dc.subjectclinical articleen_US
dc.subjectfemaleen_US
dc.subjecthistone phosphorylationen_US
dc.subjecthumanen_US
dc.subjecthuman tissueen_US
dc.subjectimmunohistochemistryen_US
dc.subjectlabeling indexen_US
dc.subjectmaleen_US
dc.subjectmeningiomaen_US
dc.subjectmiddle ageden_US
dc.subjectmitosis indexen_US
dc.subjectprotein expressionen_US
dc.subjecttumor localizationen_US
dc.subjecttumor volumeen_US
dc.subjectvery elderlyen_US
dc.titleSTAT3 Expression and Correlation Between Ki-67 and PHH3 in Meningiomas: Is it Possible to Predict Recurrence?en_US
dc.title.alternativeMeningiomlarda STAT3 Ekspresyonu ve Ki-67 ile PHH3 Arasındaki Korelasyon: Rekürrensi Öngörmek Mümkün mü?en_US
dc.typeArticleen_US

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