EXPRESSION OF AEG-1 AND P53 AND THEIR CLINICOPATHOLOGICAL SIGNIFICANCE IN MALIGNANT LESIONS OF RENAL CELL CARCINOMAS: A MICROARRAY STUDY

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dc.contributor.authorErdem, Havva
dc.contributor.authorOktay, Murat
dc.contributor.authorYıldırım, Ümran
dc.contributor.authorUzunlar, Ali Kemal
dc.contributor.authorKayıkçı, M. Ali
dc.date.accessioned2020-05-01T12:10:02Z
dc.date.available2020-05-01T12:10:02Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionoktay, murat/0000-0002-0893-4444; oktay, murat/0000-0002-0893-4444en_US
dc.descriptionWOS: 000318663900005en_US
dc.descriptionPubMed: 23625597en_US
dc.description.abstractThe aim of this study was to investigate the relationship of AEG-1 and p53 with the prognostic parameters of renal cell carcinoma (RCC). In this study, 50 paraffin blocks were histopathologically diagnosed at the Department of Pathology of the Medical Hospital of Duzce University, between 2005 and 2011. The cases consisted of 24 clear cell (CC) and 26 non-clear cell (NCC) RCC subtypes as follows: 24 (48%) clear cell RCC, 12 (24%) papillary RCC, 4 (8%) multilocular cystic RCC and 10 (20%) chromophobe RCC; none had sarcornatoid changes. By immunohistochemical analysis we investigated AEG-1 and p53 expression in carcinomas of the kidney, and by statistical analysis determined their relationship with clinicopathological parameters. Significant relationships were found between increasing tumor diameter and the increase of p53 (p = 0.028). In addition, p53 was significantly related to renal sinus invasion (p = 0.05) and Fuhrman grade (p = 0.026). There was a significant relationship between increased AEG-1 staining scores and CC and NCC carcinoma subtypes (p = 0.032), tumor capsule invasion (p = 0.01) and lymphovascular invasion (p = 0.015). There was also a significant correlation between tumor size and capsule and lymphovascular invasion (p = 0.02). We concluded that high AEG-1 and p53 expression correlates with the prognostic parameters in RCC patients, and in addition may be associated with tumor progression.en_US
dc.identifier.doi10.5114/PJP.2013.34600en_US
dc.identifier.endpage32en_US
dc.identifier.issn1233-9687
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage28en_US
dc.identifier.urihttps://doi.org/10.5114/PJP.2013.34600
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5934
dc.identifier.volume64en_US
dc.identifier.wosWOS:000318663900005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherVesalius Univ Medical Publen_US
dc.relation.ispartofPolish Journal Of Pathologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAEG-1en_US
dc.subjectp53en_US
dc.subjectprognostic parametersen_US
dc.subjectrenal cell carcinomasen_US
dc.titleEXPRESSION OF AEG-1 AND P53 AND THEIR CLINICOPATHOLOGICAL SIGNIFICANCE IN MALIGNANT LESIONS OF RENAL CELL CARCINOMAS: A MICROARRAY STUDYen_US
dc.typeArticleen_US

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