Histological Comparison of Nanocomposite Multilayer Biomimetic Scaffold, A Chondral Scaffold, and Microfracture Technique to Repair Experimental Osteochondral Defects in Rats

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dc.authorid
dc.contributor.authorSolak, Kazım
dc.contributor.authorYücel, İstemi
dc.contributor.authorKaraduman, Zekeriya Okan
dc.contributor.authorArda, Sena
dc.contributor.authorOrak, M. Müfit
dc.contributor.authorMidi, Ahmet
dc.date.accessioned2021-12-01T18:22:36Z
dc.date.available2021-12-01T18:22:36Z
dc.date.issued2020
dc.department[Belirlenecek]en_US
dc.description.abstractObjective: We used biomimetic scaffolds, chondral scaffolds, and microfractures to repair experimentally created osteochondral defects in rat knees and then compared the results of each method.Materials and Methods: We used a total of 56 female Wistar albino rats. The rats were grouped into 4 groups, with 14 rats each: biomimetic scaffold, chondral scaffold, microfracture, and control groups. Cylindrical full-thickness osteochondral defects 2.5 mm in diameter and 2 mm in depth were drilled into the right knees with the rats under general anesthesia. The knees of all rats were operated again after 4 weeks. Biomimetic and chondral scaffolds were classified into two groups. Microfractures 0.5 mm in diameter and 0.8 mm in depth were created in the rats of the microfracture group. The control group received no treatment. All the rats were observed for 6 weeks and then sacrificed, with samples subjected to macroscopic and histopathological examinations.Results: The macroscopic and histopathological results in the biomimetic scaffold group differed significantly from those of the other treatment groups (p<0.05). When we compared the 3 treatment groups, the results of the chondral scaffold group were better than those of the microfracture group. The results of the microfracture group were somewhat better than those of the control group, but the result was not statistically significant (p>0.05).Conclusions: Nanocomposite multilayer biomimetic scaffolds were better than chondral scaffolds and microfractures when used to treat osteochondral defects.en_US
dc.identifier.doi10.5152/eurasianjmed.2019.19077
dc.identifier.endpage152en_US
dc.identifier.issn1308-8734
dc.identifier.issn1308-8742
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85090692091en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage145en_US
dc.identifier.urihttps://doi.org/10.5152/eurasianjmed.2019.19077
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpneU9EWXhNUT09
dc.identifier.urihttps://hdl.handle.net/20.500.12684/9523
dc.identifier.volume52en_US
dc.identifier.wosWOS:000542299000010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.relation.ispartofEurasian Journal of Medicineen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keywords]en_US
dc.titleHistological Comparison of Nanocomposite Multilayer Biomimetic Scaffold, A Chondral Scaffold, and Microfracture Technique to Repair Experimental Osteochondral Defects in Ratsen_US
dc.typeArticleen_US

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