Unclear Issues Regarding COVID-19

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dc.authorid
dc.contributor.authorYüksel, Aycan
dc.contributor.authorKaradoğan, Dilek
dc.contributor.authorGündüz, Canan
dc.contributor.authorAkyıl, Fatma Tokgöz
dc.contributor.authorTöreyin, Zehra Nur
dc.contributor.authorMarim, Feride
dc.contributor.authorAkgün, Metin
dc.date.accessioned2021-12-01T18:22:31Z
dc.date.available2021-12-01T18:22:31Z
dc.date.issued2020
dc.department[Belirlenecek]en_US
dc.description.abstractScientists from all over the world have been intensively working to discover different aspects of Coronavirus disease 2019 (COVID-19) since the first cluster of cases was reported in China. Herein, we aimed to investigate unclear issues related to transmission and pathogenesis of disease as well as accuracy of diagnostic tests and treatment modalities. A literature search on PubMed, Ovid, and EMBASE databases was conducted, and articles pertinent to identified search terms were extracted. A snow-ball search strategy was followed in order to retrieve additional relevant articles. It was reported that viral spread may occur during the asymptomatic phase of infection, and viral load was suggested to be a useful marker to assess disease severity. In contrast to immune response against viral infections, cytotoxic T lymphocytes decline in SARS-CoV-2 infection, which can be partially explained by direct invasion of T lymphocytes or apoptosis activated by SARS-CoV-2. Dysregulation of the urokinase pathway, cleavage of the SARS-CoV-2 Spike protein by FXa and FIIa, and consumption coagulopathy were the proposed mechanisms of the coagulation dysfunction in COVID-19. False-negative rates of reverse transcriptase polymerase chain reaction varied between 3% and 41% across studies. The probability of the positive test was proposed to decrease with the number of days past from symptom onset. Safety issues related to infection spread limit the use of high flow nasal oxygen (HFNO) and continuous positive airway pressure (CPAP) in hypoxic patients. Further studies are required to elucidate the challenging issues, thus enhancing the management of COVID-19 patients.en_US
dc.identifier.doi10.5152/eurasianjmed.2020.20092
dc.identifier.endpage196en_US
dc.identifier.issn1308-8734
dc.identifier.issn1308-8742
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85087118043en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage191en_US
dc.identifier.urihttps://doi.org/10.5152/eurasianjmed.2020.20092
dc.identifier.urihttps://app.trdizin.gov.tr/makale/TXpneU9EZ3hNUT09
dc.identifier.urihttps://hdl.handle.net/20.500.12684/9503
dc.identifier.volume52en_US
dc.identifier.wosWOS:000542299000018en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.relation.ispartofEurasian Journal of Medicineen_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subject[No Keywords]en_US
dc.titleUnclear Issues Regarding COVID-19en_US
dc.typeArticleen_US

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