The Change in the Susceptible Populations with the Shift in Hepatitis A Epidemiology

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dc.authorscopusid57221847920
dc.authorscopusid55601927500
dc.authorscopusid57224925707
dc.authorscopusid57989986500
dc.authorscopusid6507441650
dc.contributor.authorŞirin, A.
dc.contributor.authorTokmak, Salih
dc.contributor.authorAkan, K.
dc.contributor.authorUlaşoğlu, H.C.
dc.contributor.authorYılmaz, Enç, F.
dc.date.accessioned2023-07-26T11:54:05Z
dc.date.available2023-07-26T11:54:05Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalıen_US
dc.description.abstractAim: The incidence of hepatitis A (HepA) has decreased due to vaccination and improved hygiene conditions. However, the age of onset of the disease has shifted from childhood to adulthood. Children with HepA are mildly symptomatic, whereas the course of the disease in adults may be severe. The aim of this study was to examine the change in HepA seroprevalence and identify the population susceptible to HepA. Material and Methods: A total of 10132 patients who were tested anti-Hepatitis A virus immunoglobulin G (anti-HAV IgG) between 2016 and 2019 were reviewed retrospectively, and included in this study. The patients were divided into five groups according to their age, and seropositivity rates were compared between age groups. The relevant data of the healthcare professionals were also evaluated separately. Results: The overall seropositivity rate was 60.1% (n=6088). The seropositivity rate was found 29.0% (n=944) in the 18 to 24 years range, 49.7% (n=837) in the 25 to 29 years range, 60.6% (n=689) in the 30 to 34 years range, 76.6% (n=784) in the 35 to 39 years range, and 93.3% (n=2834) in the ?40 years groups. The seropositivity rate was found 36.1% (n=1781) and 82.9% (n=4307) in patients <30 and ?30 years groups, respectively (p<0.001). Conclusion: In recent decades, there has been a significant change in HepA seroprevalence. This change has resulted in the emergence of a young adult population susceptible to possible HepA outbreaks. Thus, seronegative young adults may be considered at risk for HepA and routine vaccination may be considered. © 2022, Duzce University Medical School. All rights reserved.en_US
dc.identifier.doi10.18678/dtfd.1196325
dc.identifier.endpage320en_US
dc.identifier.issn1307-671X
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85144666080en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage315en_US
dc.identifier.trdizinid1146383en_US
dc.identifier.urihttps://doi.org/10.18678/dtfd.1196325
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1146383
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12721
dc.identifier.volume24en_US
dc.identifier.wosWOS:001206407600001en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.institutionauthorTokmak, Salih
dc.language.isoenen_US
dc.publisherDuzce University Medical Schoolen_US
dc.relation.ispartofDüzce Tıp Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectHepatitis Aen_US
dc.subjecthepatitis A vaccineen_US
dc.subjecthepatitis A virusen_US
dc.subjecthepatitis A antibodyen_US
dc.subjectimmunoglobulin G antibodyen_US
dc.subjectArticleen_US
dc.subjectchemiluminescent microparticle immunoassayen_US
dc.subjectfemaleen_US
dc.subjecthealth care personnelen_US
dc.subjecthepatitis Aen_US
dc.subjecthumanen_US
dc.subjectmajor clinical studyen_US
dc.subjectmaleen_US
dc.subjectretrospective studyen_US
dc.subjectseroprevalenceen_US
dc.subjectsusceptible populationen_US
dc.subjectvaccinationen_US
dc.titleThe Change in the Susceptible Populations with the Shift in Hepatitis A Epidemiologyen_US
dc.title.alternativeHepatit A Epidemiyolojisi ve Duyarlı Nüfusta Değişimen_US
dc.typeArticleen_US

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