Effect of Montelukast on Spinal Cord Ischemia-Reperfusion Injury

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dc.contributor.authorKorkmaz, Kemal
dc.contributor.authorGedik, Hikmet Selçuk
dc.contributor.authorBudak, Ali Baran
dc.contributor.authorYener, Ali Ümit
dc.contributor.authorKaya, Ertuğrul
dc.contributor.authorGenç, Serhat Bahadır
dc.contributor.authorÇağlı, Kerim
dc.date.accessioned2020-05-01T09:11:43Z
dc.date.available2020-05-01T09:11:43Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionBudak, Ali Baran/0000-0002-9772-1765; Kaya, Ertugrul/0000-0003-0081-682Xen_US
dc.descriptionWOS: 000374071900013en_US
dc.descriptionPubMed: 26442542en_US
dc.description.abstractAIM: Paraplegia due to ischemia-reperfusion (I/R) injury of the spinal cord is a devastating complication of thoracoabdominal aortic surgery. Cysteinyl leukotrienes are potent mediators of inflammation that are associated with I/R injury. The present study was designed to investigate the role of montelukast, a selective reversible CysLT1 receptor antagonist, on spinal cord I/R injury in an experimental model. MATERIAL and METHODS: Twenty-one male Sprague-Dawley rats were randomly assigned to three groups (n=7 per group) as G1 (no aortic occlusion and montelukast administration), G2 (45 min. aortic occlusion; no montelukast administration) and G3 (45 min. aortic occlusion, 10 mg/kg montelukast administration). After neurologic evaluation using the Motor Deficit Index (MDI) score at the 48th hour of reperfusion, lumbar spinal cords were removed for histopathological evaluation and immunohistochemical staining for HSP70, interleukin-6 and myeloperoxidase (MPO). RESULTS: All rats in the G1 group had a normal neurological status and their MDI score was 0 (p<0.05). The MDI score of G3 was significantly lower than G2 group (2.8 vs. 5.5; p<0.05). Vacuolar congestion was found to be significantly lower in G1 than the other groups (p=0.0001). The interleukin-6 receptor level was found to be significantly lower in G3 group than the control group (p=0.013). There was no statistically significant difference found among the groups in terms of the degree of HSP70 and MPO staining. CONCLUSION: Increased generation of leukotrienes in postischemic organs play an important role in I/R injury. The findings of the current study demonstrated that montelukast improved motor recovery and decreased IL-6 levels in spinal cord I/R injury.en_US
dc.identifier.doi10.5137/1019-5149.JTN.11499-14.2en_US
dc.identifier.endpage765en_US
dc.identifier.issn1019-5149
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage757en_US
dc.identifier.urihttps://doi.org/10.5137/1019-5149.JTN.11499-14.2
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5739
dc.identifier.volume25en_US
dc.identifier.wosWOS:000374071900013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkish Neurosurgical Socen_US
dc.relation.ispartofTurkish Neurosurgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSpinal cord ischemiaen_US
dc.subjectMontelukasten_US
dc.subjectReperfusion injuryen_US
dc.subjectRaten_US
dc.subjectExperimentalen_US
dc.subjectCysLT1 receptoren_US
dc.titleEffect of Montelukast on Spinal Cord Ischemia-Reperfusion Injuryen_US
dc.typeArticleen_US

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