The preventive effects of atorvastatin and N-acetyl cysteine in experimentally induced ischemia-reperfusion injury in rats

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dc.contributor.authorYaşar, Mehmet
dc.contributor.authorErdi, I.
dc.contributor.authorKaya, B.
dc.date.accessioned2020-04-30T23:34:08Z
dc.date.available2020-04-30T23:34:08Z
dc.date.issued2018
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000428649600008en_US
dc.descriptionPubMed: 29536746en_US
dc.description.abstractAIM: We investigated the effects of atorvastatin and N-acetyl cysteine in decreasing ischemia-reperfusion damage after detorsion of a volvulus of the cecum and ascending colon. METHODS: Wistar albino rats (250-300 g) were divided into four groups. A cecal-ascending colon volvulus was created by the intestinal clockwise 720 degrees rotation. At the end of one hour, the bowel was detorsioned. Group I (n = 7) was the sham (laparotomy) group, Group II (n = 7) the control (no treatment, volvulus or detorsion), Group III (n = 7) (N-acetyl cysteine administered), and Group IV (n = 7) (atorvastatin administered) group. Blood samples were collected from each group via peripheral veins and centrifuged one hour after detorsion. The parameters of ischemia including malondialdehyde, glutathione peroxidase, catalase, and superoxide dismutase were then observed in the serous fluid. RESULTS: Malondialdehyde and superoxide dismutase increased in the control group, whereas they were reduced in the Group III and Group IV (p = 0.005; p = 0.008, respectively). The glutathione peroxidase levels revealed no significant differences (p > 0.05), whereas the catalase levels of the group III was higher than in each of the other three groups (p < 0.001). Histopathological evaluation detected reduced lesioning of the organ in the groups which were given atorvastatin and N-acetyl cysteine. CONCLUSION: Atorvastatin and of N-acetyl cysteine have a similar preventive effect in experimental ischemia-reperfusion injury (Tab. 8, Fig. 6, Ref. 24). Text in PDF www.elis.sk.en_US
dc.identifier.doi10.4149/BLL_2017_105en_US
dc.identifier.endpage174en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage167en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2017_105
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5108
dc.identifier.volume119en_US
dc.identifier.wosWOS:000428649600008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectatorvastatinen_US
dc.subjectN-acetyl cysteineen_US
dc.subjectischemia-reperfusion injuryen_US
dc.subjectvolvulusen_US
dc.titleThe preventive effects of atorvastatin and N-acetyl cysteine in experimentally induced ischemia-reperfusion injury in ratsen_US
dc.typeArticleen_US

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