Rifaximine spacer application is not superior to local teicoplanin treatment in a rat model of osteomyelitis

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dc.contributor.authorYücel, Mücahid Osman
dc.contributor.authorTurhan, Yalçın
dc.contributor.authorArıcan, Mehmet
dc.contributor.authorKaraduman, Zekeriya Okan
dc.contributor.authorSağlam, Sönmez
dc.contributor.authorTekçe, Yıldıray
dc.contributor.authorGamsızkan, Mehmet
dc.date.accessioned2023-07-26T11:50:39Z
dc.date.available2023-07-26T11:50:39Z
dc.date.issued2022
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Ortopedi ve Travmatoloji Ana Bilim Dalıen_US
dc.description.abstractOBJECTIVE: Acute and chronic osteomyelitis generally require long-term antibiotic therapy and surgical debridement. Implant-associated osteomyelitis, particularly from methicillin-resistant Staphylococcus aureus (MRSA) strains, is difficult to treat. Rifaximin is an antibiotic derived from rifamycin which may be effective in the treatment of osteomyelitis in terms of its wide spectrum of action and pharmacological properties. The aim of this experimental study was to investigate the local efficacy of rifaximin in rat models with MRSA and implant associated osteomyelitis.METHODS: This study was carried out with 40 adult Wistar albino rats. The rats were randomly divided into 4 equal groups with 10 rats in each. An implant related MRSA osteomyelitis was created in the right tibia metaphysis of each rat by Norden's experimental osteomyelitis model. After 4 weeks, the implants of each tibia were removed and debridement was applied. Group 1 was designed as control group and no other treatment was applied other than debridement. Bone cement without any antibiotic was applied to Group 2, bone cement with teicoplanin was applied to Group 3 and bone cement with rifaximin was applied to Group 4. After 4 weeks from the second surgery, euthanasia was performed to the rats and the clinical, histopathological and microbiological results were compared.RESULTS: There was no statistically significant difference between the groups in clinical scoring. A statistically significant difference was found between the histopathological scores of Group 1 and Group 2 and the histopathological scores of Groups 3 and 4; the histopathological scores of Group 1 and Group 2 were found to be higher than Group 3 and Group 4. When the pre-and post-treatment colony numbers were compared, although there was a statistically significant difference between Group 3 and Group 2, no statistically significant difference was found between Group 4 and Group 1 results.CONCLUSION: In spite of its wide spectrum, the local efficacy of rifaximin in the treatment of osteomyelitis could not be demonstrated. This study shows the ability to shed light on some future comprehensive studies with the inclusion of infection markers.en_US
dc.description.sponsorshipDizce Universityen_US
dc.description.sponsorshipFinancial Disclosure: This study was granted by the Dizce University Scientific Researches Projects (BAP) with the number of 2018.04.02.790.en_US
dc.identifier.doi10.14744/nci.2022.04935
dc.identifier.endpage513en_US
dc.identifier.issn2148-4902
dc.identifier.issn2536-4553
dc.identifier.issue5en_US
dc.identifier.pmid36447581en_US
dc.identifier.scopus2-s2.0-85164667407en_US
dc.identifier.startpage505en_US
dc.identifier.urihttps://doi.org/10.14744/nci.2022.04935
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12398
dc.identifier.volume9en_US
dc.identifier.wosWOS:000884694100014en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.institutionauthorTurhan, Yalçın
dc.institutionauthorArıcan, Mehmet
dc.institutionauthorKaraduman, Zekeriya Okan
dc.language.isoenen_US
dc.publisherKare Publen_US
dc.relation.ispartofNorthern Clinics of Istanbulen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectMethicillin-Resistant Staphylococcus Aureus; Osteomyelitis; Rat Model; Rifaximin; Teicoplaninen_US
dc.subjectAureus Experimental Osteomyelitis; In-Vitro; Vancomycin; Rifampin; Susceptibility; Ciprofloxacin; Combination; Tigecycline; Infections; Rifamycinen_US
dc.titleRifaximine spacer application is not superior to local teicoplanin treatment in a rat model of osteomyelitisen_US
dc.typeArticleen_US

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