The interactions of nitric oxide and adenosine on penicillininduced epileptiform activity in rats

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dc.contributor.authorYıldırım, Mehmet
dc.contributor.authorMarangoz, Abdullah H.
dc.contributor.authorAyyıldız, Mustafa
dc.contributor.authorAnkaralı, Seyit
dc.contributor.authorMarangoz, Cafer
dc.date.accessioned2020-04-30T13:33:43Z
dc.date.available2020-04-30T13:33:43Z
dc.date.issued2011
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionPubMed ID: 21731075en_US
dc.description.abstractIn this study, the influence of nitric oxide (NO) and adenosine systems on penicillin-induced epileptiform activity was examined in rats. NO donor, sodium nitroprusside (SNP, 50 ?g/rat, i.c.v.) reduced the frequency but not the amplitude of epileptiform discharges. Non-selective NOS inhibitor, N-omega-nitro-L-arginine methyl ester (L-NAME, 100 ?g/rat, i.c.v.) practically did not exert any effect on the spike frequency and amplitude. Adenosine (100 ?g/rat, i.c.) reduced spike frequency but not the amplitude, whereas theophylline (100 ?g/rat, i.c.v.) increased the mean spike frequency and amplitude of penicillin-induced epileptiform discharges. Co-injection of theophylline and L-NAME did not cause a further increase in the epileptiform activity compared with theophylline. When NO production was blocked with L-NAME, the inhibitory effects of adenosine were lost. The obtained results suggest that NO and adenosine may decrease penicillin-induced epileptiform activity in rats and that NO, at least in part, may mediate the anticonvulsant effect of adenosine. © 2011 by Polish Neuroscience Society.en_US
dc.identifier.endpage219en_US
dc.identifier.issn0065-1400
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage208en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/715
dc.identifier.volume71en_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.relation.ispartofActa Neurobiologiae Experimentalisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdenosine; Ecog; Epileptiform activity; Nitric oxide; Raten_US
dc.titleThe interactions of nitric oxide and adenosine on penicillininduced epileptiform activity in ratsen_US
dc.typeArticleen_US

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