The interactions of nitric oxide and adenosine on penicillininduced epileptiform activity in rats
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Dosyalar
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, the influence of nitric oxide (NO) and adenosine systems on penicillin-induced epileptiform activity was examined in rats. NO donor, sodium nitroprusside (SNP, 50 ?g/rat, i.c.v.) reduced the frequency but not the amplitude of epileptiform discharges. Non-selective NOS inhibitor, N-omega-nitro-L-arginine methyl ester (L-NAME, 100 ?g/rat, i.c.v.) practically did not exert any effect on the spike frequency and amplitude. Adenosine (100 ?g/rat, i.c.) reduced spike frequency but not the amplitude, whereas theophylline (100 ?g/rat, i.c.v.) increased the mean spike frequency and amplitude of penicillin-induced epileptiform discharges. Co-injection of theophylline and L-NAME did not cause a further increase in the epileptiform activity compared with theophylline. When NO production was blocked with L-NAME, the inhibitory effects of adenosine were lost. The obtained results suggest that NO and adenosine may decrease penicillin-induced epileptiform activity in rats and that NO, at least in part, may mediate the anticonvulsant effect of adenosine. © 2011 by Polish Neuroscience Society.
Açıklama
PubMed ID: 21731075
Anahtar Kelimeler
Adenosine; Ecog; Epileptiform activity; Nitric oxide; Rat
Kaynak
Acta Neurobiologiae Experimentalis
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
71
Sayı
2
