The effects of ATP-dependent potassium channel opener; pinacidil, and blocker; glibenclamide, on the ischemia induced arrhythmia in partial and complete ligation of coronary artery in rats

Basit Öğe Kaydı
dc.contributor.authorYaşar, Selçuk
dc.contributor.authorBozdoğan, Ömer
dc.contributor.authorKaya, Salih Tunç
dc.contributor.authorOrallar, Hayriye Soytürk
dc.date.accessioned2020-04-30T23:33:17Z
dc.date.available2020-04-30T23:33:17Z
dc.date.issued2015
dc.departmentDÜ, Fen-Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.descriptionYASAR, Selcuk/0000-0002-9677-8823; YASAR, SELCUK/0000-0002-9677-8823; Orallar, Hayriye/0000-0002-0000-3768en_US
dc.descriptionWOS: 000352442100012en_US
dc.descriptionPubMed: 25810894en_US
dc.description.abstractObjective(s): Electrical inhomogeneity between ischemic and non ischemic myocardium is the basis of arrhythmia which occurs following coronary artery occlusion. The leakage of potassium from the ischemic region to the non ischemic region is very effective in the generation of these arrhythmias. The aim of this study is to research the effect of ATP-dependent potassium (K-ATP) channel blocker (glibenclamide) and opener (pinacidil) on ischemia induced arrhythmia in the presence of small and large infarct sizes. Materials and Methods: In this study Sprague-Dawley male rats of 8-9 months of age were used. Ischemia was produced by the partial ligation of left coronary artery ramus descending (PL) for smaller infarct and complete ligation of this artery (CL) for larger infarct for 30 min. The arrhythmia score which was calculated from the duration and type of arrhythmia was significantly higher in animals which had a larger infarct area than the animals which had a smaller infarct. Results: Glibenclamide increased the rate of arrhythmia in animals having smaller infarct but not in animals having larger infarct. Pinacidil did not affect the occurrence of arrhythmia in either group. There was a significant difference in the infarct size and risk of infarct zone between animals which had small and large infarct sizes. The effect of glibenclamide and pinacidil on the arrhythmias differed depend on decrease of infarct size. Conclusion: Glibenclamide is not effective to decrease ischemia induced arrhythmia in the presence of small and pinacidil in large ischemic zone.en_US
dc.description.sponsorshipresearch fund of Abant Izzet Baysal University, Bolu TurkeyAbant Izzet Baysal Universityen_US
dc.description.sponsorshipThis study was supported financially by the research fund of Abant Izzet Baysal University, Bolu Turkey. Some part of the results described in this paper is presented as MSc thesis in Biology Department of Faculty of Science, Abant Izzet Baysal University.en_US
dc.identifier.endpage193en_US
dc.identifier.issn2008-3866
dc.identifier.issn2008-3874
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage188en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4938
dc.identifier.volume18en_US
dc.identifier.wosWOS:000352442100012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherMashhad Univ Med Sciencesen_US
dc.relation.ispartofIranian Journal Of Basic Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArrhythmiaen_US
dc.subjectCoronary ligationen_US
dc.subjectIschemia-reperfusionen_US
dc.subjectMyocardialen_US
dc.titleThe effects of ATP-dependent potassium channel opener; pinacidil, and blocker; glibenclamide, on the ischemia induced arrhythmia in partial and complete ligation of coronary artery in ratsen_US
dc.typeArticleen_US

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