The inhibitory effects of Bevacizumab and Dexamethasone on corneal neovascularization

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dc.contributor.authorAvcıoğlu, Sedat
dc.contributor.authorÖnder, Halil İbrahim
dc.contributor.authorKaya, Murat
dc.contributor.authorErdem, Havva
dc.date.accessioned2020-04-30T23:33:52Z
dc.date.available2020-04-30T23:33:52Z
dc.date.issued2012
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000314345000012en_US
dc.description.abstractPurpose: To investigate the effect of bevacizumab and dexamethasone in the prevention of experimentally induced corneal neovascularization in a rat model. Methods: Thirty male Wistar-Albino rats weighing between 250 g and 300 g were used in the study. Silver nitrate sticks (75% silver nitrate, 25% potassium nitrate) were used to induce chemical cauterization on the corneas of 30 eyes. The rats were randomized to 1 of 5 groups and each group contained 6 rats: Group 1 (control group) without treatment; group 2 received topical 0,1% dexamethasone phosphate twice daily; group 3 received a subconjunctival injection of bevacizumab (0.1 mL, 2.5 mg); group 4 received topical 25mg/ml bevacizumab twice daily, and group 5 was treated with 0.1ml, 2.5 mg of subconjunctival bevacizumab once a day plus topical 25mg/ml bevacizumab twice daily. Corneas were evaluated by operating microscope on the tenth day. Number of major blood vessels was determined. After the examination, enucleation was performed. Histopathologic examinations were made with paraffin block, Hematoxilen-Eosin and Masson's trichrome staining. Blood vessels were counted in the histopathologic cornea sections. Cornea sections were evaluated with regard to the intensity of new vessels, collagen fibers, oedema and fibroblastic activity. Results: The corneal neovascularization in Group 1 were significantly higher than groups 2, 3, 4 and 5 (P<0.05). Corneal neovascularization in bevacizumab treated groups was less than the group treated with topical dexamethasone phosphate and the control group (p<0.05). However, there was no statistically significant difference between the three groups treated with bevacizumab (p>0.05). Masson's trichrome staining in the control group in the region below the epithelium, severe edema and collagen fibers were observed in apparent disorder and separation. The severity of symptoms was less severe in the group treated with topical dexamethasone than the control group. Collagen fibers were organized in bevacizumab treated rats and a marked edema was not observed in them. Conclusion: Bevacizumab and dexamethasone decreased the number of new blood vessels significantly in experimental corneal neovascularization model.en_US
dc.identifier.endpage3972en_US
dc.identifier.issn1840-2291
dc.identifier.issue12en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage3967en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5060
dc.identifier.volume6en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherDrunpp-Sarajevoen_US
dc.relation.ispartofHealthmeden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCorneal neovascularizationen_US
dc.subjectBevacizumaben_US
dc.subjectDexamethasoneen_US
dc.titleThe inhibitory effects of Bevacizumab and Dexamethasone on corneal neovascularizationen_US
dc.typeArticleen_US

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