Behcet's disease as a causative factor of cerebral venous sinus thrombosis: subgroup analysis of data from the VENOST study

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dc.contributor.authorUludüz, Derya
dc.contributor.authorMidi, Ipek
dc.contributor.authorDuman, Taşkın
dc.contributor.authorÇolakoğlu, Sena
dc.contributor.authorTüfekçi, Ahmet
dc.contributor.authorBakar, Mustafa
dc.contributor.authorAluçlu, Ufuk
dc.date.accessioned2020-04-30T22:40:05Z
dc.date.available2020-04-30T22:40:05Z
dc.date.issued2019
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionkarahan, ali yavuz/0000-0001-8142-913X; Kozak, Hasan Huseyin/0000-0001-6904-8545; Uzuner, Nevzat/0000-0002-4961-4332; Tascilar, Nida/0000-0003-0780-0783; Afsar, Nazire/0000-0001-8123-8560; Zeydan, Burcu/0000-0002-2270-9868; Batur Caglayan, Hale/0000-0002-3279-1842en_US
dc.descriptionWOS: 000465130500010en_US
dc.descriptionPubMed: 29992235en_US
dc.description.abstractObjective This study was performed to determine the rate of cerebral venous sinus thrombosis (CVST) among cases of Behcet's disease (BD) included in a multicentre study of cerebral venous sinus thrombosis (VENOST). Methods VENOST was a retrospective and prospective national multicentre observational study that included 1144 patients with CVST. The patients were classified according to aetiologic factors, time of CVST symptom onset, sinus involvement, treatment approach and prognosis. Results BD was shown to be a causative factor of CVST in 108 (9.4%) of 1144 patients. The mean age of patients in the BD group was 35.27 years and 68.5% were men, whereas in the non-BD CVST group, the mean age was 40.57 years and 28.3% were men (P < 0.001). Among the aetiologic factors for patients aged 18-36 years, BD was predominant for men, and puerperium was predominant for women. The onset of symptoms in the BD group was consistent with the subacute form. The transverse sinuses were the most common sites of thrombosis, followed by the superior sagittal sinuses. The most common symptom was headache (96.2%), followed by visual field defects (38%). Conclusions BD was found in 9.4% of patients in our VENOST series. Patients with BD were younger and showed a male predominance. The functional outcome of CVST in patients with BD was good; only 12% of patients presenting with cranial nerve involvement and altered consciousness at the beginning had a poor outcome (modified Rankin Score 2).en_US
dc.identifier.doi10.1093/rheumatology/key153en_US
dc.identifier.endpage608en_US
dc.identifier.issn1462-0324
dc.identifier.issn1462-0332
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage600en_US
dc.identifier.urihttps://doi.org/10.1093/rheumatology/key153
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2901
dc.identifier.volume58en_US
dc.identifier.wosWOS:000465130500010en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofRheumatologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBehcet's diseaseen_US
dc.subjectcerebral venous sinus thrombosisen_US
dc.subjectoutcomeen_US
dc.subjectsubgroup analysisen_US
dc.subjectVENOST studyen_US
dc.titleBehcet's disease as a causative factor of cerebral venous sinus thrombosis: subgroup analysis of data from the VENOST studyen_US
dc.typeArticleen_US

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