Inhibition of Angiotensin-II Production Increases Susceptibility to Acute Ischemia/Reperfusion Arrhythmia

dc.contributor.authorTaşkın, Eylem
dc.contributor.authorTuncer, Kadir Ali
dc.contributor.authorGüven, Celal
dc.contributor.authorKaya, Salih Tunç
dc.contributor.authorDursun, Nurcan
dc.date.accessioned2020-04-30T23:18:31Z
dc.date.available2020-04-30T23:18:31Z
dc.date.issued2016
dc.departmentDÜ, Fen-Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.descriptionGuven, Celal/0000-0003-0499-7787en_US
dc.descriptionWOS: 000388507800001en_US
dc.descriptionPubMed: 27889788en_US
dc.description.abstractBackground: Myocardial ischemia and reperfusion lead to impairment of electrolyte balance and, eventually, lethal arrhythmias. The aim of this study was to investigate the effects of pharmacological inhibition of angiotensin-II (Ang-II) production on heart tissue with ischemia-reperfusion damage, arrhythmia, and oxidative stress. Material/Methods: Rats were divided into 4 groups: only ischemia/reperfusion (MI/R), captopril (CAP), aliskiren (AL), and CAP+AL. The drugs were given by gavage 30 min before anesthesia. Blood pressure and electrocardiography (ECG) were recorded during MI/R procedures. The heart tissue and plasma was kept so as to evaluate the total oxidant (TOS), antioxidant status (TAS), and creatine kinase-MB (CK-MB). Results: Creatine kinase-MB was not different among the groups. Although TAS was not affected by inhibition of Ang-II production, TOS was significantly lower in the CAP and/or AL groups than in the MI/R group. Furthermore, oxidative stress index was significantly attenuated in the CAP and/or AL groups. Captopril significantly increased the duration of VT during ischemia; however, it did not have any effect on the incidence of arrhythmias. During reperfusion periods, aliskiren and its combinations with captopril significantly reduced the incidence of other types of arrhythmias. Captopril alone had no effect on the incidence of arrhythmias, but significantly increased arrhythmias score and durations of arrhythmias during reperfusion. MAP and heart rate did not show changes in any groups during ischemic and reperfusion periods. Conclusions: Angiotensin-II production appears to be associated with elevated levels of reactive oxygen species, but Ang-II inhibitions increases arrhythmia, mainly by initiating ventricular ectopic beats.en_US
dc.description.sponsorshipResearch Foundation of Erciyes UniversityErciyes University [TSY-09-734]en_US
dc.description.sponsorshipThis study was financially supported by the Research Foundation of Erciyes University (TSY-09-734)en_US
dc.identifier.doi10.12659/MSM.896350en_US
dc.identifier.endpage4595en_US
dc.identifier.issn1643-3750
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage4587en_US
dc.identifier.urihttps://doi.org/10.12659/MSM.896350
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3375
dc.identifier.volume22en_US
dc.identifier.wosWOS:000388507800001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherInt Scientific Literature, Incen_US
dc.relation.ispartofMedical Science Monitoren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectArrhythmiasen_US
dc.subjectCardiacen_US
dc.subjectCaptoprilen_US
dc.subjectOxidative Stressen_US
dc.subjectRenin-Angiotensin Systemen_US
dc.subjectReperfusion Injuryen_US
dc.titleInhibition of Angiotensin-II Production Increases Susceptibility to Acute Ischemia/Reperfusion Arrhythmiaen_US
dc.typeArticleen_US

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