Effects of Walnut Septum on The Enzyme Pathways Associated with Plasma Cholesterol Level

Basit Öğe Kaydı
dc.contributor.authorSirin, Neslihan
dc.contributor.authorCoskun, Nuri Cenk
dc.contributor.authorAdem, Sevki
dc.date.accessioned2024-08-23T16:03:50Z
dc.date.available2024-08-23T16:03:50Z
dc.date.issued2024en_US
dc.departmentDüzce Üniversitesien_US
dc.description.abstractObjective: Cholesterol is crucial compound that plays pivotal role in cellular function in living organisms. Its excess or deficiency in plasma can lead to destruction and disintegration of cell membrane structure. Maintaining balanced intake of cholesterol in diet and seeking medical treatment, if necessary, can help prevent these negative effects. Furthermore, people often resort to natural and herbal remedies, such as walnut septum. Due to dearth of scientific data regarding effects of walnut septum on cholesterol metabolism, this research was undertaken to explore its potential effects. Methods: Analysis was begun by extracting septum using various solvents. Resulting extracts were then analyzed using GC-MS, and compounds were identified by using an integrated library database. To detect effects of extracts on cholesterol esterase and HMGCoA reductase, a colorimetric method was employed. Results: Monophenol, 2,4-Di-tert-butylphenol, 2,6-Di-tert-butylphenol, ethyl linoleate, and butyl linoleate were some of compounds detected by GC-MS scanning. The highest inhibitions were observed in the enzymatic analysis, with a rate of 3.2% (acetone) in the HMG-CoA reductase analysis and 13.6% (water) in the cholesterol esterase analysis. Conclusions: Although the walnut septum extract contains various chemical compounds, our in vitro analysis data suggest that there is no inhibitory effect at therapeutic level on enzyme pathways that regulate plasma cholesterol levels, namely HMG-CoA reductase and cholesterol esterase. We believe that further research is necessary to comprehensively evaluate its effects on other pathways.en_US
dc.description.sponsorshipDuzce University [2019.04.03.1032]en_US
dc.description.sponsorshipThis article was created from the results of PhD thesis and the thesis project was supported by Duzce University Research Fund Project Number: 2019.04.03.1032. We thank Duzce University.en_US
dc.identifier.doi10.18521/ktd.1332992
dc.identifier.endpage147en_US
dc.identifier.issn1309-3878
dc.identifier.issue2en_US
dc.identifier.startpage140en_US
dc.identifier.trdizinid1246563en_US
dc.identifier.urihttps://doi.org/10.18521/ktd.1332992
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1246563
dc.identifier.urihttps://hdl.handle.net/20.500.12684/13930
dc.identifier.volume16en_US
dc.identifier.wosWOS:001278068300001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherDuzce Univ, Fac Medicineen_US
dc.relation.ispartofKonuralp Tıp Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectWalnut Septumen_US
dc.subjectHMG-CoA Reductaseen_US
dc.subjectCholesterol Esteraseen_US
dc.subjectGC-MSen_US
dc.subjectInhibitory-Activityen_US
dc.subjectAntioxidanten_US
dc.subjectEsteraseen_US
dc.subjectExtractsen_US
dc.titleEffects of Walnut Septum on The Enzyme Pathways Associated with Plasma Cholesterol Levelen_US
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
13930.pdf
Boyut:
2.58 MB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Konuralp Tip Dergisi Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu