AMELIORATING EFFECT OF HAWTHORN (CRATAEGUS OXYACANTHA) AND PHYSICAL EXERCISE ON ACUTE PENICILLIN INDUCED SEIZURES IN GERBILS

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dc.contributor.authorÇakır, Serkan
dc.contributor.authorOrallar, Hayriye
dc.contributor.authorÇetinkaya, Ayhan
dc.contributor.authorKayacan, Yıldırım
dc.contributor.authorÖnal, Ali Can
dc.contributor.authorYıldırım, Arzu
dc.contributor.authorOkur, Nezih
dc.date.accessioned2020-04-30T22:39:06Z
dc.date.available2020-04-30T22:39:06Z
dc.date.issued2016
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionCETINKAYA, Ayhan/0000-0002-8212-7149; Orallar, Hayriye/0000-0002-0000-3768; YILDIRIM, Arzu Birinci/0000-0001-7712-2813en_US
dc.descriptionWOS: 000372926800026en_US
dc.description.abstractBackground: The aim of the present study was to assess the effect of Hawthorn (Crataegus oxyacantha) and physical activity. We studied its effect on penicillin induced epilepsy. in gerbils. Materal and Methods: Epilepsy was induced by administration of peniciline G (500 IU, ip). The gerbils were divided randomly in four groups (6 animals per each group) and studied as described below: 1) Control group 2) Exercise group (30 min/each day for 8 weeks) (Eg) 3) Extract group, 50mg/kg/day/animal in 1 ml saline, 3 h prior to exercise (Exe) 4) Exercise+ Extract + (Exe+ Ex). The severity of epilepsy was observed and recorded. Results: The means of latencies (Mean +/- SE) were 236 +/- 45, 369 +/- 36, 386 +/- 58 and 433 +/- 37 ms in groups of control, Exe, Ex, and Exe+ Ex respectively. The mean spike latency significantly (P= 0,033 F= 3,560) decreased in Exe, Ex and Exe+ Ex when compared control. Although spike frequency significantly (P< 0.05) diminished in groups of Exe and Ex, no significant decrease was observed in control and Exe+ Ex. Similar trend was seen for amplitude values. Spike amplitude values were determined to be significantly (P< 0.05) lower than those of control and Exe+ Ex. Conclusion: Crataegus oxyacantha extract has shown positive affect to ameliorate on some seizure parameters in this study. However, further more advanced physiologic and neurochemical studies are required to determine the mechanisms involved.en_US
dc.description.sponsorshipResearch Found of Abant Izzet Baysal UniversityAbant Izzet Baysal University [2005.10.03.879]en_US
dc.description.sponsorshipThis study was supported by Research Found of Abant Izzet Baysal University with the number of 2005.10.03.879.en_US
dc.identifier.doi10.4314/ajtcam.v13i2.26en_US
dc.identifier.endpage228en_US
dc.identifier.issn0189-6016
dc.identifier.issue2en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage223en_US
dc.identifier.urihttps://doi.org/10.4314/ajtcam.v13i2.26
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2601
dc.identifier.volume13en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherAfrican Networks Ethnomedicinesen_US
dc.relation.ispartofAfrican Journal Of Traditional Complementary And Alternative Medicinesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCrataegus oxyacanthaen_US
dc.subjectphysical activityen_US
dc.subjectepilepsyen_US
dc.subjectgerbilen_US
dc.titleAMELIORATING EFFECT OF HAWTHORN (CRATAEGUS OXYACANTHA) AND PHYSICAL EXERCISE ON ACUTE PENICILLIN INDUCED SEIZURES IN GERBILSen_US
dc.typeArticleen_US

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