AMELIORATING EFFECT OF HAWTHORN (CRATAEGUS OXYACANTHA) AND PHYSICAL EXERCISE ON ACUTE PENICILLIN INDUCED SEIZURES IN GERBILS
Yükleniyor...
Dosyalar
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
African Networks Ethnomedicines
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: The aim of the present study was to assess the effect of Hawthorn (Crataegus oxyacantha) and physical activity. We studied its effect on penicillin induced epilepsy. in gerbils. Materal and Methods: Epilepsy was induced by administration of peniciline G (500 IU, ip). The gerbils were divided randomly in four groups (6 animals per each group) and studied as described below: 1) Control group 2) Exercise group (30 min/each day for 8 weeks) (Eg) 3) Extract group, 50mg/kg/day/animal in 1 ml saline, 3 h prior to exercise (Exe) 4) Exercise+ Extract + (Exe+ Ex). The severity of epilepsy was observed and recorded. Results: The means of latencies (Mean +/- SE) were 236 +/- 45, 369 +/- 36, 386 +/- 58 and 433 +/- 37 ms in groups of control, Exe, Ex, and Exe+ Ex respectively. The mean spike latency significantly (P= 0,033 F= 3,560) decreased in Exe, Ex and Exe+ Ex when compared control. Although spike frequency significantly (P< 0.05) diminished in groups of Exe and Ex, no significant decrease was observed in control and Exe+ Ex. Similar trend was seen for amplitude values. Spike amplitude values were determined to be significantly (P< 0.05) lower than those of control and Exe+ Ex. Conclusion: Crataegus oxyacantha extract has shown positive affect to ameliorate on some seizure parameters in this study. However, further more advanced physiologic and neurochemical studies are required to determine the mechanisms involved.
Açıklama
CETINKAYA, Ayhan/0000-0002-8212-7149; Orallar, Hayriye/0000-0002-0000-3768; YILDIRIM, Arzu Birinci/0000-0001-7712-2813
WOS: 000372926800026
WOS: 000372926800026
Anahtar Kelimeler
Crataegus oxyacantha, physical activity, epilepsy, gerbil
Kaynak
African Journal Of Traditional Complementary And Alternative Medicines
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
13
Sayı
2
