Acute myocardial infarction associated with clomiphene citrate in a young woman

dc.contributor.authorAvşar, Şahin
dc.contributor.authorÖz, Ahmet
dc.contributor.authorAvşar, Aydan Köken
dc.contributor.authorKaya, Adnan
dc.contributor.authorBörklü, Edibe Betül
dc.date.accessioned2020-04-30T22:38:59Z
dc.date.available2020-04-30T22:38:59Z
dc.date.issued2018
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000446494100008en_US
dc.descriptionPubMed: 30024398en_US
dc.description.abstractClomiphene citrate is a drug that stimulates ovulation and is commonly used in cases of female infertility. Generally, it is recognized as a safe agent for ovulation induction, but rarely, it is associated with life-threatening conditions. A 36-year-old woman who had been prescribed clomiphene citrate for infertility was admitted to the emergency department for chest pain lasting for 2 hours. She had no history of smoking, and she did not have any cardiac risk factor for myocardial infarction (MI). An electrocardiogram performed on admission revealed ST-elevation in the precordial leads. She was taken to the catheter laboratory for ST-elevation myocardial infarction, and the coronary angiography revealed total occlusion of the midportion of the left anterior descending artery (LAD) with a heavy thrombus burden. The circumflex and right coronary arteries were normal. After balloon dilatation, a 2.75x15-mm drug eluting stent was implanted in the mid part of the LAD. The patient had an uncomplicated recovery. Before discharge, echocardiography revealed apical akinesis; anterior and lateral hypokinesis; and an ejection fraction of 45% with mild mitral regurgitation. Although clomiphene citrate is a relatively safe drug for ovarian stimulation, it has been associated with serious side effects, such as MI. Physicians should be aware of the potential risks of clomiphene citrate, especially in patients with risk factors for coronary artery disease.en_US
dc.identifier.doi10.5543/tkda.2017.55237en_US
dc.identifier.endpage405en_US
dc.identifier.issn1016-5169
dc.identifier.issue5en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage401en_US
dc.identifier.urihttps://doi.org/10.5543/tkda.2017.55237
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2549
dc.identifier.volume46en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkish Soc Cardiologyen_US
dc.relation.ispartofTurk Kardiyoloji Dernegi Arsivi-Archives Of The Turkish Society Of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute myocardial infarctionen_US
dc.subjectclomiphene citrateen_US
dc.subjectcoronary arteryen_US
dc.subjectdrug induced thrombosisen_US
dc.titleAcute myocardial infarction associated with clomiphene citrate in a young womanen_US
dc.typeArticleen_US

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