Association of clinicopathological features with E-cadherin (CDH1) gene-160 C > A promoter polymorphism in Turkish colorectal cancer patients
Loading...
Files
Date
2019
Journal Title
Journal ISSN
Volume Title
Publisher
Wolters Kluwer Medknow Publications
Access Rights
info:eu-repo/semantics/openAccess
Abstract
Background and Aim of Study: The role of E-cadherin (CDH1) gene-160 C>A (rsl 6260) promoter polymorphism in colorectal cancer (CRC) still remains inconclusive. The aim of this study is to investigate the associations between the CDH1 -160 C>A polymorphism with the susceptibility and clinicopathological development of CRC in the Turkish patients. To our knowledge, this is the first report examining the role of CDH1 polymorphism in Turkish CRC patients. Materials and Methods: A total of 92 colorectal carcinoma cases (including 62 colon and 30 rectal cancer patients) and the corresponding adjacent normal tissues as controls were studied. The polymorphism was genotyped using polymerase chain reaction-restriction fragment length polymorphism analysis. Clinicopathological features including patient's age, gender, tumor stage, and tumor location (colon/ rectum) were compared statistically with the polymorphism status. Results: There was no significant difference in both genotype and allele frequencies of the CDH1 polymorphism between colorectal tumor cases and normal samples (P = 0.472 and 0.508, respectively). Furthermore, no significant associations were observed between the CDH1 polymorphism status and age, gender, tumor stage, and tumor location of the colorectal tumor cases (all P>0.05). Conclusions: These results indicate that CDH1 -160 C>A polymorphism does not contribute to the genetic susceptibility of CRC and the polymorphism may not be a direct effect on the progression of the disease in Turkish CRC patients.
Description
WOS: 000461542500005
PubMed: 30880750
PubMed: 30880750
Keywords
Clinicopathological features, colorectal cancer, E-cadherin (CDH1)-160 C > A polymorphism, polymerase chain reaction-restriction fragment length polymorphism analysis, susceptibility
Journal or Series
Journal Of Cancer Research And Therapeutics
WoS Q Value
Q4
Scopus Q Value
Q3
Volume
15
Issue
1
