Synthesis and Characterization of Copper-Nanoflowers with the Utilization of Medicinal Plant Extracts for Enhanced Various Enzyme Inhibitory Activities

dc.authoridÇalışkan, Ufuk Koca/0000-0002-5216-7588
dc.authoridAltınkaynak, Cevahir/0000-0003-0082-8521
dc.authorid, Nuraniye/0000-0002-4674-7009
dc.authorwosidÇalışkan, Ufuk Koca/HIU-0019-2022
dc.contributor.authorKoca Çalışkan, Ufuk
dc.contributor.authorDönmez, Ceylan
dc.contributor.authorEruygur, Nuraniye
dc.contributor.authorAyaz, Fatma
dc.contributor.authorAltınkaynak, Cevahir
dc.contributor.authorÖzdemir, Nalan
dc.date.accessioned2023-07-26T11:51:24Z
dc.date.available2023-07-26T11:51:24Z
dc.date.issued2022
dc.departmentDÜ, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractIn this study, organic-inorganic hybrid nanoflowers were synthesized using methanolic extracts of the medicinal plants Ajuga chamaepitys subsp. chia var. chia, Achillea wilhelmsii, Bongardia chrysogonum, Malva sylvestris, Phlomis grandiflora var. grandiflora, Verbascum sp. together with copper ions (Cu2+). The synthesized plant extract based-inorganic hybrid nanoflowers (PE-ihNFs) of A. chamaepitys subsp. chia var. chia (Ac-ihNFs), A. wilhelmsii (Aw-ihNfs), B. chrysogonum (Bc-ihNFs), M. sylvestris (Ms-ihNFs) P. grandiflora var. grandiflora (Pg-ihNFs), and Verbascum sp. (Vs-ihNFs) were characterized by Scanning Electron Microscopy (SEM), Energy-Dispersive X-ray (EDX), Fourier transform infrared spectrometry (FTIR), and X-Ray Diffraction (XRD). Also, several enzymes were selected to evaluate the enzyme inhibition activities of the synthesized PE-ihNFs. For the first-time, enzymes, tyrosinase, alpha-amylase and alpha-glucosidase, acetyl and butyryl cholinesterase inhibition activities of the PE-ihNFs with comparison to their plain plant extracts were evaluated in vitro. Results show that the among all the analyzed PE-ihNFs, demonstrated better alpha-glucosidase & alpha-amylase enzyme inhibition activity compared to the plain extracts. These initial studies are promising for the synthesis of these hybrid nanoflowers containing medicinal plant extracts, which might have commercial applications in the pharmaceutical and dermo-cosmetics industries.en_US
dc.description.sponsorshipGazi University laboratory; Erciyes University laboratoryen_US
dc.description.sponsorshipAnalyses were performed with the support of Gazi and Erciyes University laboratories.en_US
dc.identifier.doi10.1002/cbdv.202200476
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.issue11en_US
dc.identifier.pmid36149402en_US
dc.identifier.scopus2-s2.0-85139436710en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/cbdv.202200476
dc.identifier.urihttps://hdl.handle.net/20.500.12684/12554
dc.identifier.volume19en_US
dc.identifier.wosWOS:000864404900001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.institutionauthorÇalışkan, Ufuk Koca
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistry & Biodiversityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz$2023V1Guncelleme$en_US
dc.subjectEnzyme Inhibitions; Hybrid Nanoflowers; Medicinal Plants; Plants Extracten_US
dc.subjectInorganic Hybrid Nanoflowers; Bioassay-Guided Isolation; Antimicrobial Activity; Traditional Medicine; Chemical-Composition; Iridoid Glycosides; Alpha-Glucosidase; Essential Oil; Tyrosinase; L.en_US
dc.titleSynthesis and Characterization of Copper-Nanoflowers with the Utilization of Medicinal Plant Extracts for Enhanced Various Enzyme Inhibitory Activitiesen_US
dc.typeArticleen_US

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