Resveratrol attenuates oxidative stress and histological alterations induced by liver ischemia/reperfusion in rats

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dc.contributor.authorGedik, Ercan
dc.contributor.authorGirgin, Sadullah
dc.contributor.authorÖztürk, Hayrettin
dc.contributor.authorObay, Basra Deniz
dc.contributor.authorÖztürk, Hülya
dc.contributor.authorBüyükbayram, Hüseyin
dc.date.accessioned2020-04-30T23:31:41Z
dc.date.available2020-04-30T23:31:41Z
dc.date.issued2008
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000261768200008en_US
dc.descriptionPubMed: 19084917en_US
dc.description.abstractAIM: To investigate the effects of resveratrol on liver ischemia/reperfusion (I/R) injury in rats. METHODS: A total of 40 male Sprague-Dawley rats weighing 240-290 g were randomized into four groups of ten: (1) controls: data from unmanipulated animals; (2) sham group: rats subjected to the surgical procedure, except for liver I/R, and given saline; (3) I/R group: rats underwent liver ischemia for 45 min followed by reperfusion for 45 min; (4) I-R/Resveratrol group: rats pretreated with resveratrol (10 mu mol/L, iv). Liver tissues were obtained to determine antioxidant enzyme levels and for biochemical and histological evaluation. RESULTS: Plasma aminotransferase activities were higher in the I/R group than in the I-R/Resveratrol group. Malondialdehyde levels and the hepatic injury score decreased, while superoxide dismutase, catalase, and glutathione peroxidase levels increased in group 4 compared to group 3. In group 4, histopathological changes were significantly attenuated in resveratrol-treated livers. CONCLUSION: These results suggest that resveratrol has protective effects against hepatic I/R injury, and is a potential therapeutic drug for ischemia reperfusionrelated liver injury. (C) 2008 The WIG Press. All rights reserved.en_US
dc.identifier.doi10.3748/wjg.14.7101en_US
dc.identifier.endpage7106en_US
dc.identifier.issn1007-9327
dc.identifier.issn2219-2840
dc.identifier.issue46en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage7101en_US
dc.identifier.urihttps://doi.org/10.3748/wjg.14.7101
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4408
dc.identifier.volume14en_US
dc.identifier.wosWOS:000261768200008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherBaishideng Publishing Group Incen_US
dc.relation.ispartofWorld Journal Of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectInjuryen_US
dc.subjectIschemia/reperfusionen_US
dc.subjectLiveren_US
dc.subjectResveratrolen_US
dc.titleResveratrol attenuates oxidative stress and histological alterations induced by liver ischemia/reperfusion in ratsen_US
dc.typeArticleen_US

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