Clinical assessment of patients with acromegaly

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dc.contributor.authorGökosmanoğlu, Feyzi
dc.contributor.authorÖnmez, Attila
dc.date.accessioned2020-04-30T22:40:52Z
dc.date.available2020-04-30T22:40:52Z
dc.date.issued2018
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000444510600003en_US
dc.descriptionPubMed: 30181743en_US
dc.description.abstractBackground: In this study, we aimed to retrospectively evaluate treatment outcomes and treatment methods in acromegaly patients. Materials and Methods: The study included 65 acromegaly patients followed in Sakarya University Faculty of Medicine Department of Endocrinology in Turkey between 2004 and 2013. Clinical, biochemical, and radiological data were obtained retrospectively from the medical files of the patients. All cases have been discussed in the endocrinology and pituitary surgery council, and a multidisciplinary treatment approach had been chosen in management. Results: Sixty-five patients were included in the study. Of the patients, 57% were female. Mean age was 45.3 +/- 9.2 years old. Of the cases, 12.3% were microadenomas (n = 8, tumor diameter < 10 mm) and 87.6% were macroadenomas (n = 57, tumor diameter = 10 mm). In our study, 70% remission was achieved with the first operation and medical treatment. Patients with invasive acromegaly without remission after the first operation underwent reoperation, medical treatment, and conventional or stereotactic radiotherapy and achieved 45% remission rate. Conclusion: Pituitary surgery is the first treatment option for acromegaly. In patients who could not be remissioned after the first operation, remission can be achieved by combined therapy consist of reoperation, medical treatment, and conventional or stereotactic radiotherapy.en_US
dc.identifier.doi10.4103/jrms.JRMS_139_17en_US
dc.identifier.issn1735-1995
dc.identifier.issn1735-7136
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.4103/jrms.JRMS_139_17
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3075
dc.identifier.volume23en_US
dc.identifier.wosWOS:000444510600003en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofJournal Of Research In Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcromegalyen_US
dc.subjectpituitary glanden_US
dc.subjecttreatmenten_US
dc.titleClinical assessment of patients with acromegalyen_US
dc.typeArticleen_US

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