Clinical assessment of patients with acromegaly
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Date
2018
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Wolters Kluwer Medknow Publications
Access Rights
info:eu-repo/semantics/openAccess
Abstract
Background: In this study, we aimed to retrospectively evaluate treatment outcomes and treatment methods in acromegaly patients. Materials and Methods: The study included 65 acromegaly patients followed in Sakarya University Faculty of Medicine Department of Endocrinology in Turkey between 2004 and 2013. Clinical, biochemical, and radiological data were obtained retrospectively from the medical files of the patients. All cases have been discussed in the endocrinology and pituitary surgery council, and a multidisciplinary treatment approach had been chosen in management. Results: Sixty-five patients were included in the study. Of the patients, 57% were female. Mean age was 45.3 +/- 9.2 years old. Of the cases, 12.3% were microadenomas (n = 8, tumor diameter < 10 mm) and 87.6% were macroadenomas (n = 57, tumor diameter = 10 mm). In our study, 70% remission was achieved with the first operation and medical treatment. Patients with invasive acromegaly without remission after the first operation underwent reoperation, medical treatment, and conventional or stereotactic radiotherapy and achieved 45% remission rate. Conclusion: Pituitary surgery is the first treatment option for acromegaly. In patients who could not be remissioned after the first operation, remission can be achieved by combined therapy consist of reoperation, medical treatment, and conventional or stereotactic radiotherapy.
Description
WOS: 000444510600003
PubMed: 30181743
PubMed: 30181743
Keywords
Acromegaly, pituitary gland, treatment
Journal or Series
Journal Of Research In Medical Sciences
WoS Q Value
Q3
Scopus Q Value
Q3
Volume
23
