Comparison of effects on the oxidant/antioxidant system of sevoflurane, desflurane and propofol infusion during general anesthesia

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dc.contributor.authorErbaş, Mesut
dc.contributor.authorDemiraran, Yavuz
dc.contributor.authorYıldırım, Hayriye Ak
dc.contributor.authorSezen, Gülbin
dc.contributor.authorİskender, Abdülkadir
dc.contributor.authorKaragöz, İbrahim
dc.contributor.authorKandiş, Hayati
dc.date.accessioned2020-04-30T22:41:16Z
dc.date.available2020-04-30T22:41:16Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionKandis, Hayati/0000-0001-9151-6050en_US
dc.descriptionWOS: 000348246300011en_US
dc.descriptionPubMed: 25443441en_US
dc.description.abstractBackground and objectives: Desflurane and sevoflurane are frequently used for maintenance of anesthesia and studies have shown that these anesthetics cause a variety of changes to the oxidative stress and antioxidative defense mechanisms. This study aims to compare the effects of sevoflurane, desflurane and propofol infusion anesthesia on the oxidant and antioxidant systems of patients undergoing laparoscopic cholecystectomy. Methods: 45 patients between 18 and 50 years with planned laparoscopic cholecystectomy under general anesthetic were included in the study. Patients were divided into three groups on the way to surgery: propofol (group P n: 15), sevoflurane (group S n: 15) and desfiurane (group D n: 15). All groups were given hypnotic 2 mg/kg propofol IV, 1 mcg/kg fentanyl IV and 0.1 mg/kg vecuronium IV for induction. For maintenance of anesthesia group S were ventilated with 2% sevoflurane, group D cases were given 6% desflurane and group P were given propofol infusions of 12 mg/kg/h for the first 10 min, 9 rrig/kg/h for the second 10 min and 6 mg/kg/h after that. Before induction and after the operation venous blood samples were taken to evaluate the levels of glutation peroxidase, total oxidants and antioxidants. Results and conclusions: The 45 patients included in the study were 22 male and 23 female patients. The demographic characteristics of the groups were similar. In the postoperative period we observed that while sevoflurane and propofol increased antioxidants by a statistically significant level, desfiurane increased the total oxidants level by a significant amount compared to levels before the operation. (C) 2014 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.en_US
dc.identifier.endpage72en_US
dc.identifier.issn0034-7094
dc.identifier.issn1806-907X
dc.identifier.issue1en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage68en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3155
dc.identifier.volume65en_US
dc.identifier.wosWOS:000348246300011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofRevista Brasileira De Anestesiologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOxidanten_US
dc.subjectAntioxidanten_US
dc.subjectPropofolen_US
dc.subjectGeneral anesthesiaen_US
dc.titleComparison of effects on the oxidant/antioxidant system of sevoflurane, desflurane and propofol infusion during general anesthesiaen_US
dc.typeArticleen_US

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