Pregnancy-associated plasma protein-A: Evaluation of a new biomarker in renal transplant patients

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dc.contributor.authorCoşkun, Abdurrahman
dc.contributor.authorDuran, Sadık
dc.contributor.authorApaydın, S.
dc.contributor.authorBulut, İsmet
dc.contributor.authorSarıyar, Muzaffer
dc.date.accessioned2020-04-30T23:21:28Z
dc.date.available2020-04-30T23:21:28Z
dc.date.issued2007
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionCoskun, Abdurrahman/0000-0002-1273-0604en_US
dc.descriptionWOS: 000252037900028en_US
dc.descriptionPubMed: 18089325en_US
dc.description.abstractObjective. Trophoblasts produce high concentrations of pregnancy-associated plasma protein-A (PAPP-A) during pregnancy. PAPP-A has been described as a new inflammatory marker and an independent risk factor for posttransplant cardiovascular risk. This study evaluated the clinical significance of PAPP-A in renal transplant patients. Methods. The study included 78 adult renal transplant patients (56 men and 22 women) and 37 control subjects (27 men and 10 women). We determined serum PAPP-A, urea, creatinine, uric acid, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglyceride, 24-hour proteinuria, and C-reactive protein (CRP) levels. Results. The PAPP-A level was significantly higher among renal transplant patients [median (interquartile range), 10.5 (6.4 to 15.4) mU/L] than the control group [3.9 (3.1 to 5.2) mU/L; P <.001]. There were significant positive correlations between serum PATP-A levels and urea (r =.547, P =.001), creatinine (r =.497, P =.001), uric acid (r =.452, P =.001), and CRP values (r =.387, P =.001). The drugs used for immunosuppression in transplant patients (cyclosporine, tacrolimus, and others) did not significantly affect serum PAPP-A levels (P >.05). Conclusion. We concluded that PAPP-A level was elevated in renal transplant patients and that high levels of PAPP-A might be a prognostic marker owing to their close association with high serum levels of urea, creatinine, uric acid, and CRP.en_US
dc.identifier.doi10.1016/j.transproceed.2007.08.111en_US
dc.identifier.endpage3076en_US
dc.identifier.issn0041-1345
dc.identifier.issn1873-2623
dc.identifier.issue10en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage3072en_US
dc.identifier.urihttps://doi.org/10.1016/j.transproceed.2007.08.111
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4198
dc.identifier.volume39en_US
dc.identifier.wosWOS:000252037900028en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofTransplantation Proceedingsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.titlePregnancy-associated plasma protein-A: Evaluation of a new biomarker in renal transplant patientsen_US
dc.typeArticleen_US

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