Short-term diabetes decreases ischemia reperfusion-induced arrhythmia: the effect of alpha-2 blocker yohimbine and glibenclamide

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dc.contributor.authorBozdoğan, Ömer
dc.contributor.authorKaya, Salih Tunç
dc.contributor.authorYaşar, Selçuk
dc.contributor.authorBaş, Erçin Çağdaş
dc.contributor.authorÖzarslan, Oğulcan Talat
dc.contributor.authorEkşioğlu, Didem
dc.contributor.authorErim, Firdevs
dc.date.accessioned2020-04-30T23:31:56Z
dc.date.available2020-04-30T23:31:56Z
dc.date.issued2016
dc.departmentDÜ, Fen-Edebiyat Fakültesi, Biyoloji Bölümüen_US
dc.descriptionYASAR, Selcuk/0000-0002-9677-8823; YASAR, SELCUK/0000-0002-9677-8823; Yasar, Selcuk/0000-0002-7529-9751; Ozarslan, Talat Ogulcan/0000-0002-2635-7011en_US
dc.descriptionWOS: 000378689600019en_US
dc.description.abstractThis study examined the effect of yohimbine alone and in combination with glibenclamide on ischemia and reperfusion-induced arrhythmias in diabetes. Six minutes of ischemia were produced in 1-week diabetic rats by ligation of the left coronary artery, and 6 min of reperfusion were produced by releasing the artery. A dose of 5 mg/kg of yohimbine and glibenclamide was administered for 7 days prior to the coronary ligation. The blood pressure, heart rate, and arrhythmia were determined from the recorded ECG during the 6 min of ischemia and reperfusion and then compared using a one-way ANOVA statistical program and the chi-square test. The score of arrhythmia calculated from the type and duration of arrhythmia decreased in the diabetic rats (3.5 +/- 1.69 in control, 1.7 +/- 0.81 in diabetes group). The arrhythmia score returned to the control value in the rats that were given a combination of yohimbine and glibenclamide (3 +/- 1.73). Yohimbine is used in the treatment of erectile dysfunction; glibenclamide is used as an antidiabetic drug in diabetic patients and may be a risk factor in the increase of ischemia reperfusion-induced arrhythmias.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113Z851]en_US
dc.description.sponsorshipWe would like to thank the Scientific and Technological Research Council of Turkey (TUBITAK) for supporting this study with project number 113Z851.en_US
dc.identifier.doi10.3906/biy-1510-42en_US
dc.identifier.endpage905en_US
dc.identifier.issn1300-0152
dc.identifier.issn1303-6092
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage899en_US
dc.identifier.urihttps://doi.org/10.3906/biy-1510-42
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4538
dc.identifier.volume40en_US
dc.identifier.wosWOS:000378689600019en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIschemiaen_US
dc.subjectreperfusionen_US
dc.subjectarrhythmiaen_US
dc.subjectdiabetesen_US
dc.subjectglibenclamideen_US
dc.subjectyohimbineen_US
dc.titleShort-term diabetes decreases ischemia reperfusion-induced arrhythmia: the effect of alpha-2 blocker yohimbine and glibenclamideen_US
dc.typeArticleen_US

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