Serum visfatin and omentin levels in slow coronary flow

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dc.contributor.authorUçgun, Taner
dc.contributor.authorBaşar, Cengiz
dc.contributor.authorMemişoğulları, Ramazan
dc.contributor.authorDemirin, Hilmi
dc.contributor.authorTürker, Yasin
dc.contributor.authorAslantaş, Yusuf
dc.date.accessioned2020-04-30T23:31:54Z
dc.date.available2020-04-30T23:31:54Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000347270500006en_US
dc.descriptionPubMed: 25481776en_US
dc.description.abstractObjective: The adipocytokines visfatin and omentin have a direct effect on inflammation and endothelial injury. The expression of visfatin is closely associated with the expression of proin-flam matory cytokines. Omentin has an anti-inflammatory effect and is inversely associated with coronary artery disease (CAD). The slow coronary flow phenomenon is an angiographic finding characterized by delayed distal vessel opacification in the absence of significant epicardial coronary disease. The pathophysiology of SCF has not been clearly identified, although multiple abnormalities including endothelial dysfunction, atherothrombosis and inflammation have been reported. However, the relationship between visfatin, omentin and SCF is still unknown. In this study, we aimed to investigate the relationship of these adipocytokines with SCF. Methods: The study included slow coronary flow (n=45) and normal coronary flow (n=55) subjects, according to the corrected TIMI frame count, who underwent angiography in the catheterization laboratory of Duzce University. Statistical analyses were performed with SPSS version 12. Results: Visfatin levels were significantly higher in patients with SCF than in controls (p<0.001). Plasma omentin levels were lower in the SCF group than in controls, although without statistical significance. Visfatin, gender and platelet count were significant predictors of SCF in multivariate logistic regression analysis (OR 0.748, 95% CI 0.632-0.886, p=0.01; OR 30.016, 95% CI 4.355-206.8, p=0.01; OR1.028, 95% CI 1.006-1.050, p=0.011, respectively). Conclusion: Adipocytokines such as visfatin and omentin may play a role in the pathogenesis of coronary slow flow. (C) 2014 Sociedade Portuguesa de Cardiologia. Published by Elsevier Espana, S.L.U. All rights reserved.en_US
dc.identifier.doi10.1016/j.repc.2014.04.007en_US
dc.identifier.endpage796en_US
dc.identifier.issn0870-2551
dc.identifier.issn0304-4750
dc.identifier.issue12en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage791en_US
dc.identifier.urihttps://doi.org/10.1016/j.repc.2014.04.007
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4524
dc.identifier.volume33en_US
dc.identifier.wosWOS:000347270500006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Doyma Slen_US
dc.relation.ispartofRevista Portuguesa De Cardiologiaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSlow coronary flowen_US
dc.subjectVisfatinen_US
dc.subjectOmentinen_US
dc.titleSerum visfatin and omentin levels in slow coronary flowen_US
dc.typeArticleen_US

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