Preventive effects of coenzyme Q(10) (CoQ(10)) on steroid-induced osteonecrosis in rats

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dc.contributor.authorKömürcü, Erkam
dc.contributor.authorOktay, Murat
dc.contributor.authorKaymaz, Burak
dc.contributor.authorGölge, Umut Hatay
dc.contributor.authorGöksel, Ferdi
dc.contributor.authorNusran, Gürdal
dc.date.accessioned2020-04-30T23:21:38Z
dc.date.available2020-04-30T23:21:38Z
dc.date.issued2014
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionoktay, murat/0000-0002-0893-4444en_US
dc.descriptionWOS: 000335199800019en_US
dc.descriptionPubMed: 24747633en_US
dc.description.abstractObjective: The aim of this study was to examine the role of coenzyme Q(10) (CoQ(10)) in the prevention of steroid-induced osteonecrosis of the femoral head (ONFH) in rats. Methods: The study included 20 Sprague-Dawley rats injected once with 20 mg/kg of methylprednisolone acetate into the right gluteus medius muscle to induce osteonecrosis. Animals were divided into two equal groups; Group 1 received no prophylaxis (control group) and the Group 2 received CoQ(10). Hematological examinations were performed before steroid injection (0 weeks) and at 4 weeks after steroid injection. Femoral heads were examined histologically to evaluate osteonecrosis. Results: Changes in blood glutathione (GSH) and malondialdehyde (MDA) concentrations were less significant in the CoQ(10) group. The incidence of histologic changes consistent with early osteonecrosis was lower in the CoQ(10) group (2 of 10; 20%) than the control group (7 of 10; 70%). Conclusion: Coenzyme Q(10) may be useful as a preventing agent in steroid-induced ONFH. Inhibited oxidative stress is a possible mechanism for this effect.en_US
dc.identifier.doi10.3944/AOTT.2014.13.0150en_US
dc.identifier.endpage222en_US
dc.identifier.issn1017-995X
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage217en_US
dc.identifier.urihttps://doi.org/10.3944/AOTT.2014.13.0150
dc.identifier.urihttps://hdl.handle.net/20.500.12684/4225
dc.identifier.volume48en_US
dc.identifier.wosWOS:000335199800019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Orthopaedics Traumatologyen_US
dc.relation.ispartofActa Orthopaedica Et Traumatologica Turcicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCoenzyme Q(10)en_US
dc.subjectglutathioneen_US
dc.subjectmalondialdehydeen_US
dc.subjectsteroid-induced osteonecrosisen_US
dc.titlePreventive effects of coenzyme Q(10) (CoQ(10)) on steroid-induced osteonecrosis in ratsen_US
dc.typeArticleen_US

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