AEG-1 expression in invasive ductal and lobular breast cancers and its relationship with prognostic parameters

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dc.contributor.authorErdem, Havva
dc.contributor.authorOktay, Murat
dc.contributor.authorUzunlar, Ali Kemal
dc.contributor.authorYıldırım, Ümran
dc.contributor.authorAnkaralı, Handan
dc.contributor.authorYaşar, Mehmet
dc.date.accessioned2020-04-30T22:39:02Z
dc.date.available2020-04-30T22:39:02Z
dc.date.issued2013
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionoktay, murat/0000-0002-0893-4444; Ankarali, Handan Camdeviren/0000-0002-3613-0523; oktay, murat/0000-0002-0893-4444;en_US
dc.descriptionWOS: 000321227400017en_US
dc.description.abstractAim: The astrocyte-elevated gene-1 (AEG-1, also known as metadherin) is associated with various aspects of tumour malignancy; however, little knowledge is available related to the role of AEG-1 in ductal and lobular carcinomas. The aim of this study was to investigate the relationship of AEG-1 with the prognostic parameters in invasive ductal and lobular carcinomas. Materials and methods: This study was conducted on a total of 72 paraffin-embedded breast tumour samples. They consisted of 61 ductal and 11 lobular carcinomas. Breast tumour samples were stained for AEG-1. The prognostic parameters were compared with the results of AEG-1 stains. Results: We observed that more ductal carcinoma types than lobular carcinoma types resulted in high AEG-1 staining, whereas low AEG-1 staining occurred more in lobular carcinomas than in ductal carcinomas (P = 0.05). A significant negative correlation was also found between HER-2 (r = -0.30, P = 0.019) and AEG-1 (r = -0.804, P = 0.003) in lobular carcinomas. A significant relationship was found between increasing numbers of positive lymph nodes and AEG-1 in ductal carcinoma cases (P = 0.05). Conclusion: These results are consistent with previous reports of the role of AEG-1 in tumour progression. AEG-1 could be a useful marker for the development of new treatments and resistant hormonal therapy.en_US
dc.identifier.doi10.3906/sag-1203-43en_US
dc.identifier.endpage98en_US
dc.identifier.issn1300-0144
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage93en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1203-43
dc.identifier.urihttps://hdl.handle.net/20.500.12684/2569
dc.identifier.volume43en_US
dc.identifier.wosWOS:000321227400017en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDuctal carcinomasen_US
dc.subjectlobular carcinomasen_US
dc.subjectAEG-1en_US
dc.subjectprognostic parametersen_US
dc.titleAEG-1 expression in invasive ductal and lobular breast cancers and its relationship with prognostic parametersen_US
dc.typeArticleen_US

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