Evaluation of nasal mucociliary clearance time in patients with Vitamin-D deficiency

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dc.contributor.authorAkcan, Fatih Alper
dc.contributor.authorDündar, Yusuf
dc.contributor.authorAkcan, Hümeyra Bayram
dc.contributor.authorUluat, Ahmet
dc.contributor.authorCebeci, Derya
dc.contributor.authorÜnlü, İlhan
dc.date.accessioned2020-05-01T12:15:32Z
dc.date.available2020-05-01T12:15:32Z
dc.date.issued2019
dc.departmentDÜ, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000462155700018en_US
dc.descriptionPubMed: 30643962en_US
dc.description.abstractObjectivesThe main purpose of the current study was to investigate nasal mucociliary clearance time (NMC) in patients with Vitamin-D deficiency.MethodsA total of 55 patients with Vitamin-D deficiency and 32 controls were evaluated. NMC time was measured with subjective saccharine test and compared between study and control groups. In addition, NMC time was re-evaluated after Vitamin-D replacement protocol in patients with Vitamin-D deficiency.ResultsThe mean 25(HO)Vitamin-D levels were 14.324.23ng/mL (7-24.6) and 29.38 +/- 7.05ng/mL (25-53.8) in study and control groups, respectively (p<0.001). The mean NMC time was 11.15 +/- 3.05 (6.3-17.6) and 8.40 +/- 2.33 (6-13.2) in study and control groups, respectively (p<0.001). The mean 25(HO)Vitamin-D level after the replacement protocol was 33.38 +/- 10.03 and the mean NMC time was 9.56 +/- 2.54 (p<0.001).Conclusion The mean NMC time was significantly increased in patients with Vitamin-D deficiency which can be corrected after Vitamin-D replacement protocols. The prolonged mucociliary clearance might be one of the pathophysiologic pathways at increased upper respiratory tract infections, and sinonasal and ear infections in patients with Vitamin-D deficiency.en_US
dc.identifier.doi10.1007/s00405-019-05286-yen_US
dc.identifier.endpage1080en_US
dc.identifier.issn0937-4477
dc.identifier.issn1434-4726
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1075en_US
dc.identifier.urihttps://doi.org/10.1007/s00405-019-05286-y
dc.identifier.urihttps://hdl.handle.net/20.500.12684/6405
dc.identifier.volume276en_US
dc.identifier.wosWOS:000462155700018en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Archives Of Oto-Rhino-Laryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVitamin-Den_US
dc.subjectNasal mucociliary clearanceen_US
dc.subjectUpper respiratory tract infectionen_US
dc.subjectEar infectionen_US
dc.titleEvaluation of nasal mucociliary clearance time in patients with Vitamin-D deficiencyen_US
dc.typeArticleen_US

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