Melatonin may have a role in the pathogenesis of functional dyspepsia in males

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dc.contributor.authorErmiş, Fatih
dc.contributor.authorUyanıkoğlu, Ahmet
dc.contributor.authorAkyüz, Filiz
dc.contributor.authorYönal, Oya
dc.contributor.authorKeskin, Fahriye
dc.contributor.authorÇiftçi, Sevgi
dc.contributor.authorMungan, Zeynel
dc.date.accessioned2020-04-30T23:19:11Z
dc.date.available2020-04-30T23:19:11Z
dc.date.issued2015
dc.departmentDÜ, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümüen_US
dc.descriptionUyanikoglu, Ahmet/0000-0003-4881-5244;en_US
dc.descriptionWOS: 000369540900032en_US
dc.descriptionPubMed: 26698268en_US
dc.description.abstractOBJECTIVE: Pathogenesis of functional dyspepsia (FD) is complex. Melatonin is synthesized in enterochromaffin cells (EC) of the digestive system. It may influence gut function. The aim of this study is to evaluate the serum melatonin levels in FD patients. PATIENTS AND METHODS: A total of 57 FD patients, and 12 healthy controls were enrolled in this study between 2008-2010 years. Diagnosis of FD was established based on the Rome III Criteria. Blood samples were taken at 10 a. m. and serum samples were stored in -85 degrees C. Serum melatonin levels were determined by an enzyme-linked immunosorbent assay (ELISA) kit. (polyclonal Kennaway G280 anti-melatonin antibody, Buhlmann Laboratories AG, Schonenbuch, Switzerland). RESULTS: Twenty-three (40.3%) patients were male, and, mean age was 44.3 +/- 12.1 years. Mean age of control group was 38.5 +/- 11.8 years, and 7 of them were male. The mean serum concentration of melatonin in patients and control group were 31.19 +/- 43.4 pg/ml and 14.8 +/- 20.9 pg/ml, respectively (p < 0.05). Melatonin levels were significantly higher in male patients (38.6 +/- 55 pg/ml vs 12.8 +/- 22 pg/ml, p < 0.05). However, melatonin levels were similar in females (p > 0.05). CONCLUSIONS: The serum melatonin levels were significantly higher in male patients with functional dyspepsia. High nocturnal melatonin secretion may play a role in the pathogenesis of functional dyspepsia, especially in males.en_US
dc.identifier.endpage4678en_US
dc.identifier.issn1128-3602
dc.identifier.issue23en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage4675en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/3677
dc.identifier.volume19en_US
dc.identifier.wosWOS:000369540900032en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherVerduci Publisheren_US
dc.relation.ispartofEuropean Review For Medical And Pharmacological Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMelatoninen_US
dc.subjectFunctional dyspepsiaen_US
dc.subjectPathogenesisen_US
dc.subjectRome III criteriaen_US
dc.titleMelatonin may have a role in the pathogenesis of functional dyspepsia in malesen_US
dc.typeArticleen_US

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