Melatonin may have a role in the pathogenesis of functional dyspepsia in males
Yükleniyor...
Dosyalar
Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Verduci Publisher
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
OBJECTIVE: Pathogenesis of functional dyspepsia (FD) is complex. Melatonin is synthesized in enterochromaffin cells (EC) of the digestive system. It may influence gut function. The aim of this study is to evaluate the serum melatonin levels in FD patients. PATIENTS AND METHODS: A total of 57 FD patients, and 12 healthy controls were enrolled in this study between 2008-2010 years. Diagnosis of FD was established based on the Rome III Criteria. Blood samples were taken at 10 a. m. and serum samples were stored in -85 degrees C. Serum melatonin levels were determined by an enzyme-linked immunosorbent assay (ELISA) kit. (polyclonal Kennaway G280 anti-melatonin antibody, Buhlmann Laboratories AG, Schonenbuch, Switzerland). RESULTS: Twenty-three (40.3%) patients were male, and, mean age was 44.3 +/- 12.1 years. Mean age of control group was 38.5 +/- 11.8 years, and 7 of them were male. The mean serum concentration of melatonin in patients and control group were 31.19 +/- 43.4 pg/ml and 14.8 +/- 20.9 pg/ml, respectively (p < 0.05). Melatonin levels were significantly higher in male patients (38.6 +/- 55 pg/ml vs 12.8 +/- 22 pg/ml, p < 0.05). However, melatonin levels were similar in females (p > 0.05). CONCLUSIONS: The serum melatonin levels were significantly higher in male patients with functional dyspepsia. High nocturnal melatonin secretion may play a role in the pathogenesis of functional dyspepsia, especially in males.
Açıklama
Uyanikoglu, Ahmet/0000-0003-4881-5244;
WOS: 000369540900032
PubMed: 26698268
WOS: 000369540900032
PubMed: 26698268
Anahtar Kelimeler
Melatonin, Functional dyspepsia, Pathogenesis, Rome III criteria
Kaynak
European Review For Medical And Pharmacological Sciences
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
19
Sayı
23
