Effect of Metformin or Gliclazide on Lipid Peroxidation and Antioxidant Levels in Patients with Diabetes Mellitus

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dc.contributor.authorMemişoğulları, Ramazan
dc.contributor.authorTürkeli, Mehmet
dc.contributor.authorBakan, Ebubekir
dc.contributor.authorAkçay, Fatih
dc.date.accessioned2020-05-01T09:11:43Z
dc.date.available2020-05-01T09:11:43Z
dc.date.issued2008
dc.departmentDÜ, Tıp Fakültesi, Temel Tıp Bilimleri Bölümüen_US
dc.descriptionWOS: 000262928800007en_US
dc.description.abstractAim: The association between oxidative stress and diabetic complications is well known. The main goal of antidiabetic therapy is to prevent the complications of diabetes. Gliclazide (sulfonylurea) and metformin (biguanide) are two oral antidiabetic drugs that have been proven to prevent diabetic complications. In this study, we aimed to investigate the antioxidant effects of gliclazide or metformin. Materials and Methods: In this study. we evaluated 46 patients with type 2 diabetes mellitus. The patients were divided into three groups according to their treatment modality of gliclazide, metformin, or diet. Erythrocyte glutathione peroxidase (Gpx). glutathione S-transferase (GST), and catalase (CAT) activities and malondialdehyde (MDA) and glutathione (GSH) levels of the patients were measured and compared. Results: The erythrocyte Gpx, GST, and CAT activities were significantly higher, whereas MDA levels were significantly lower in both gliclazide and metformin groups when compared with the diet group. There was no statistically significant difference between gliclazide and metformin groups in terms of activities of antioxidant enzymes and levels of MDA. In addition, GSH levels were not different among the groups. Conclusions: The data obtained in this study showed that gliclazide or metformin administration may decrease oxidative stress. and both drugs had similar effects.en_US
dc.identifier.endpage548en_US
dc.identifier.issn1300-0144
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage545en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12684/5738
dc.identifier.volume38en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetes mellitusen_US
dc.subjectgliclazideen_US
dc.subjectmetforminen_US
dc.subjectantioxidant enzymesen_US
dc.subjectmalondialdehydeen_US
dc.titleEffect of Metformin or Gliclazide on Lipid Peroxidation and Antioxidant Levels in Patients with Diabetes Mellitusen_US
dc.typeArticleen_US

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